Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation

Kato Tamotsu, Fukuda Shinji, Fujiwara Akemi, Suda Wataru, Hattori Masahira, Kikuchi Jun, Ohno Hiroshi, Osamu Ohara

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Fructooligosaccharide (FOS), a prebiotic well known for its health-promoting properties, can improve the human gut ecosystem most likely through changes in its microbial composition. However, the detailed mechanism(s) of action of FOS in the modulation of the gut ecosystem remain(s) obscure. Traditional methods of profiling microbes and metabolites could barely show any significant features due to the existence of large interindividual differences, but our novel microbe-metabolite correlation approach, combined with faecal immunoglobulin A (IgA) measurements, has revealed that the induction of mucosal IgA by FOS supplementation correlated with the presence of specific bacteria. Furthermore, the metabolic dynamics of butyrate, L-phenylalanine, L-lysine and tyramine were positively correlated with that of these bacteria and IgA production, whereas p-cresol was negatively correlated. Taken together, our focused intraindividual analysis with omics approaches is a powerful strategy for uncovering the gut molecular network and could provide a new vista for understanding the human gut ecosystem.

Original languageEnglish
Pages (from-to)469-480
Number of pages12
JournalDNA Research
Volume21
Issue number5
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Prebiotics
Symbiosis
Immunoglobulin A
Ecosystem
Bacteria
Tyramine
Butyrates
Phenylalanine
Lysine
Health
fructooligosaccharide

Keywords

  • Commensal microbiota
  • Correlation analysis
  • Gut ecosystem
  • Metabolite
  • Prebiotics

ASJC Scopus subject areas

  • Medicine(all)
  • Molecular Biology
  • Genetics

Cite this

Tamotsu, K., Shinji, F., Akemi, F., Wataru, S., Masahira, H., Jun, K., ... Ohara, O. (2014). Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation. DNA Research, 21(5), 469-480. https://doi.org/10.1093/dnares/dsu013

Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation. / Tamotsu, Kato; Shinji, Fukuda; Akemi, Fujiwara; Wataru, Suda; Masahira, Hattori; Jun, Kikuchi; Hiroshi, Ohno; Ohara, Osamu.

In: DNA Research, Vol. 21, No. 5, 2014, p. 469-480.

Research output: Contribution to journalArticle

Tamotsu, K, Shinji, F, Akemi, F, Wataru, S, Masahira, H, Jun, K, Hiroshi, O & Ohara, O 2014, 'Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation', DNA Research, vol. 21, no. 5, pp. 469-480. https://doi.org/10.1093/dnares/dsu013
Tamotsu, Kato ; Shinji, Fukuda ; Akemi, Fujiwara ; Wataru, Suda ; Masahira, Hattori ; Jun, Kikuchi ; Hiroshi, Ohno ; Ohara, Osamu. / Multiple omics uncovers host-gut microbial mutualism during prebiotic fructooligosaccharide supplementation. In: DNA Research. 2014 ; Vol. 21, No. 5. pp. 469-480.
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