Multiple smooth muscle tumors arising in deep soft tissue of lower limbs with uterine leiomyomas

Keisuke Horiuchi, Hiroo Yabe, Makio Mukai, Hideo Morioka, Yasuhiro Udagawa, Shirou Nozawa, Yutaka Yabe

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A 40-year-old woman had multiple smooth muscle tumors in the left inguinal region, the bilateral thighs, the omenturn, the peritoneum, and the right infundibulum pelvic ligament associated with uterine leiomyomas. She had a history of uterine leiomyomas, which were resected 13 years ago. Histopathologic evaluation revealed tumor masses composed of smooth muscle cells with relatively low cellularity, which were consistent with a diagnosis of leiomyoma. Tumor necrosis and nuclear atypia were absent. Mitotic figures were very scarce (less than 1 mitotic figure per 10 high-power fields). Immunohistochemical evaluation revealed a positive reaction of the tumor cells to muscle markers, estrogen receptors, and progesretune receptors. No pulmonary lesion was found. Similar instances of uterine leiomyomas with histologically benign extrauterine smooth muscle tumors have been reported. This curious condition has been referred to as 'benign metastasizing leiomyoma,' in which most of the reported cases involve the lungs. The distribution of extrauterine tumors in our case is very unusual and may be the first case with multiple leiomyomas in deep soft tissue of the limbs. Consideration was given to the concept that these may be of multifocal origin, rather than metastases.

Original languageEnglish
Pages (from-to)897-901
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume22
Issue number7
DOIs
Publication statusPublished - 1998

Fingerprint

Smooth Muscle Tumor
Leiomyoma
Lower Extremity
Neoplasms
Lung
Groin
Peritoneum
Pituitary Gland
Thigh
Ligaments
Estrogen Receptors
Muscle Cells
Smooth Muscle Myocytes
Necrosis
Extremities
Neoplasm Metastasis

Keywords

  • Benign metastasizing leiomyoma
  • Leiomyoma
  • Leiomyosarcoma
  • Multifocal origin

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Multiple smooth muscle tumors arising in deep soft tissue of lower limbs with uterine leiomyomas. / Horiuchi, Keisuke; Yabe, Hiroo; Mukai, Makio; Morioka, Hideo; Udagawa, Yasuhiro; Nozawa, Shirou; Yabe, Yutaka.

In: American Journal of Surgical Pathology, Vol. 22, No. 7, 1998, p. 897-901.

Research output: Contribution to journalArticle

Horiuchi, Keisuke ; Yabe, Hiroo ; Mukai, Makio ; Morioka, Hideo ; Udagawa, Yasuhiro ; Nozawa, Shirou ; Yabe, Yutaka. / Multiple smooth muscle tumors arising in deep soft tissue of lower limbs with uterine leiomyomas. In: American Journal of Surgical Pathology. 1998 ; Vol. 22, No. 7. pp. 897-901.
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