Abstract
A 40-year-old woman had multiple smooth muscle tumors in the left inguinal region, the bilateral thighs, the omenturn, the peritoneum, and the right infundibulum pelvic ligament associated with uterine leiomyomas. She had a history of uterine leiomyomas, which were resected 13 years ago. Histopathologic evaluation revealed tumor masses composed of smooth muscle cells with relatively low cellularity, which were consistent with a diagnosis of leiomyoma. Tumor necrosis and nuclear atypia were absent. Mitotic figures were very scarce (less than 1 mitotic figure per 10 high-power fields). Immunohistochemical evaluation revealed a positive reaction of the tumor cells to muscle markers, estrogen receptors, and progesretune receptors. No pulmonary lesion was found. Similar instances of uterine leiomyomas with histologically benign extrauterine smooth muscle tumors have been reported. This curious condition has been referred to as 'benign metastasizing leiomyoma,' in which most of the reported cases involve the lungs. The distribution of extrauterine tumors in our case is very unusual and may be the first case with multiple leiomyomas in deep soft tissue of the limbs. Consideration was given to the concept that these may be of multifocal origin, rather than metastases.
| Original language | English |
|---|---|
| Pages (from-to) | 897-901 |
| Number of pages | 5 |
| Journal | American Journal of Surgical Pathology |
| Volume | 22 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1998 |
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Keywords
- Benign metastasizing leiomyoma
- Leiomyoma
- Leiomyosarcoma
- Multifocal origin
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
Cite this
Multiple smooth muscle tumors arising in deep soft tissue of lower limbs with uterine leiomyomas. / Horiuchi, Keisuke; Yabe, Hiroo; Mukai, Makio; Morioka, Hideo; Udagawa, Yasuhiro; Nozawa, Shirou; Yabe, Yutaka.
In: American Journal of Surgical Pathology, Vol. 22, No. 7, 1998, p. 897-901.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multiple smooth muscle tumors arising in deep soft tissue of lower limbs with uterine leiomyomas
AU - Horiuchi, Keisuke
AU - Yabe, Hiroo
AU - Mukai, Makio
AU - Morioka, Hideo
AU - Udagawa, Yasuhiro
AU - Nozawa, Shirou
AU - Yabe, Yutaka
PY - 1998
Y1 - 1998
N2 - A 40-year-old woman had multiple smooth muscle tumors in the left inguinal region, the bilateral thighs, the omenturn, the peritoneum, and the right infundibulum pelvic ligament associated with uterine leiomyomas. She had a history of uterine leiomyomas, which were resected 13 years ago. Histopathologic evaluation revealed tumor masses composed of smooth muscle cells with relatively low cellularity, which were consistent with a diagnosis of leiomyoma. Tumor necrosis and nuclear atypia were absent. Mitotic figures were very scarce (less than 1 mitotic figure per 10 high-power fields). Immunohistochemical evaluation revealed a positive reaction of the tumor cells to muscle markers, estrogen receptors, and progesretune receptors. No pulmonary lesion was found. Similar instances of uterine leiomyomas with histologically benign extrauterine smooth muscle tumors have been reported. This curious condition has been referred to as 'benign metastasizing leiomyoma,' in which most of the reported cases involve the lungs. The distribution of extrauterine tumors in our case is very unusual and may be the first case with multiple leiomyomas in deep soft tissue of the limbs. Consideration was given to the concept that these may be of multifocal origin, rather than metastases.
AB - A 40-year-old woman had multiple smooth muscle tumors in the left inguinal region, the bilateral thighs, the omenturn, the peritoneum, and the right infundibulum pelvic ligament associated with uterine leiomyomas. She had a history of uterine leiomyomas, which were resected 13 years ago. Histopathologic evaluation revealed tumor masses composed of smooth muscle cells with relatively low cellularity, which were consistent with a diagnosis of leiomyoma. Tumor necrosis and nuclear atypia were absent. Mitotic figures were very scarce (less than 1 mitotic figure per 10 high-power fields). Immunohistochemical evaluation revealed a positive reaction of the tumor cells to muscle markers, estrogen receptors, and progesretune receptors. No pulmonary lesion was found. Similar instances of uterine leiomyomas with histologically benign extrauterine smooth muscle tumors have been reported. This curious condition has been referred to as 'benign metastasizing leiomyoma,' in which most of the reported cases involve the lungs. The distribution of extrauterine tumors in our case is very unusual and may be the first case with multiple leiomyomas in deep soft tissue of the limbs. Consideration was given to the concept that these may be of multifocal origin, rather than metastases.
KW - Benign metastasizing leiomyoma
KW - Leiomyoma
KW - Leiomyosarcoma
KW - Multifocal origin
UR - http://www.scopus.com/inward/record.url?scp=0031819824&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031819824&partnerID=8YFLogxK
U2 - 10.1097/00000478-199807000-00012
DO - 10.1097/00000478-199807000-00012
M3 - Article
C2 - 9669352
AN - SCOPUS:0031819824
VL - 22
SP - 897
EP - 901
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
SN - 0147-5185
IS - 7
ER -