Multivalent Effect in Influenza Hemagglutinin-Binding Activity of Sugar-Mimic Peptide

Teruhiko Matsubara, Ai Onishi, Tomomi Saito, Daisuke Yamaguchi, Toshinori Sato

Research output: Contribution to journalArticle

Abstract

Hemagglutinin (HA) of the influenza virus binds to sialyloligosaccaride receptors on the cell surface in the first step of infection; therefore, inhibitors of the HA-receptor interaction have potential as anti-influenza drugs. We previously identified the HA-binding peptide s2, ARLPRTMVHPKPAQP, from random peptide libraries using phage-display technology. The N-stearoyl s2 peptide showed inhibitory activity against influenza virus infection. To obtain molecules with high affinity for HAs, truncated s2 peptides and dendrimers were designed in the present study. The affinity of dendrimers functionalized with the truncated peptide was higher than that of the full-length s2 peptide, especially a tetrameric dendrimer with ARLPR was more than 70-times more effective than the s2 peptide.

Original languageEnglish
Pages (from-to)62-68
Number of pages7
JournalKobunshi Ronbunshu
Volume73
Issue number1
DOIs
Publication statusPublished - 2016

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influenza
Hemagglutinins
Sugars
peptide
Peptides
sugar
Dendrimers
Viruses
virus
Peptide Library
Bacteriophages
tebufenozide
effect
Display devices
inhibitor
drug
Molecules
Pharmaceutical Preparations

Keywords

  • Anti-viral drug
  • Hemagglutinin
  • Influenza
  • Peptide
  • Sialyloligosaccharide

ASJC Scopus subject areas

  • Polymers and Plastics
  • Environmental Science(all)
  • Materials Science (miscellaneous)
  • Chemical Engineering (miscellaneous)

Cite this

Multivalent Effect in Influenza Hemagglutinin-Binding Activity of Sugar-Mimic Peptide. / Matsubara, Teruhiko; Onishi, Ai; Saito, Tomomi; Yamaguchi, Daisuke; Sato, Toshinori.

In: Kobunshi Ronbunshu, Vol. 73, No. 1, 2016, p. 62-68.

Research output: Contribution to journalArticle

Matsubara, Teruhiko ; Onishi, Ai ; Saito, Tomomi ; Yamaguchi, Daisuke ; Sato, Toshinori. / Multivalent Effect in Influenza Hemagglutinin-Binding Activity of Sugar-Mimic Peptide. In: Kobunshi Ronbunshu. 2016 ; Vol. 73, No. 1. pp. 62-68.
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