Musashi: A translational regulator of cell fate

Hideyuki Okano, Takao Imai, Masataka Okabe

Research output: Contribution to journalArticle

262 Citations (Scopus)

Abstract

Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi, for example, controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signalling by repressing translation of the Notch inhibitor m-Numb.

Original languageEnglish
Pages (from-to)1355-1359
Number of pages5
JournalJournal of Cell Science
Volume115
Issue number7
Publication statusPublished - 2002 Apr 1

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Keywords

  • Asymmetric cell division
  • Cell fate
  • Musashi
  • Neural stem cell
  • Notch signaling
  • RNA-binding protein
  • Translational regulation

ASJC Scopus subject areas

  • Cell Biology

Cite this

Okano, H., Imai, T., & Okabe, M. (2002). Musashi: A translational regulator of cell fate. Journal of Cell Science, 115(7), 1355-1359.