Abstract
Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi, for example, controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signalling by repressing translation of the Notch inhibitor m-Numb.
| Original language | English |
|---|---|
| Pages (from-to) | 1355-1359 |
| Number of pages | 5 |
| Journal | Journal of Cell Science |
| Volume | 115 |
| Issue number | 7 |
| Publication status | Published - 2002 Apr 1 |
Keywords
- Asymmetric cell division
- Cell fate
- Musashi
- Neural stem cell
- Notch signaling
- RNA-binding protein
- Translational regulation
ASJC Scopus subject areas
- Cell Biology