Muscle architectural properties in the common marmoset (Callithrix jacchus)

Naomichi Ogihara, Motoharu Oishi, Ryogo Kanai, Hikaru Shimada, Takahiro Kondo, Kimika Yoshino-Saito, Junichi Ushiba, Hideyuki Okano

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The common marmoset, Callithrix jacchus, is a small New World monkey that has recently gained attention as an important experimental animal model in the field of neuroscience as well in rehabilitative and regenerative medicine. This attention reflects the closer phylogenetic relationship between humans and common marmosets compared to that between humans and other experimental animals. When studying the neuronal mechanism behind various types of neurological motor disorders using the common marmoset, possible differences in muscle parameters (e.g., the force-generating capacity of each of the muscles) between the common marmoset and other animals must be taken into account to permit accurate interpretation of observed motor behavior. Differences in the muscle architectural properties are expected to affect biomechanics, and hence to affect neuronal control of body movements. Therefore, we dissected the forelimbs and hind limbs of two common marmosets, including systematic analysis of the muscle mass, fascicle length, and physiological cross-sectional area (PCSA). Comparisons of the mass fractions and PCSA fractions of the forelimb and hind limb musculature among the common marmoset, human, Japanese macaque, and domestic cat demonstrated that the overall muscle architectural properties of the forelimbs and hind limbs in the common marmoset are very similar to those of the Japanese macaque, a typical quadrupedal primate. However, muscle architectural properties of the common marmoset differ from those of the domestic cat, which has relatively larger hamstrings and pedal digital flexor muscles. Compared to humans, the common marmoset exhibits relatively smaller shoulder protractor, retractor, and abductor muscles and larger elbow extensor and rotator-cuff muscles in the forelimb, and smaller plantarflexor muscles in the hind limb. These differences in the muscle architectural properties must be taken into account when interpreting motor behaviors such as locomotion and arm-reaching movements in the common marmoset.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalPrimates
DOIs
Publication statusAccepted/In press - 2017 May 8

Fingerprint

Callithrix jacchus
muscles
forelimbs
limbs (animal)
Macaca fuscata
laboratory animals
cats
Cebidae
neurophysiology
elbows
shoulders
locomotion
medicine
Primates
animal models

Keywords

  • Muscle architecture
  • Muscle force
  • Physiological cross-sectional area

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

Ogihara, N., Oishi, M., Kanai, R., Shimada, H., Kondo, T., Yoshino-Saito, K., ... Okano, H. (Accepted/In press). Muscle architectural properties in the common marmoset (Callithrix jacchus). Primates, 1-12. https://doi.org/10.1007/s10329-017-0608-9

Muscle architectural properties in the common marmoset (Callithrix jacchus). / Ogihara, Naomichi; Oishi, Motoharu; Kanai, Ryogo; Shimada, Hikaru; Kondo, Takahiro; Yoshino-Saito, Kimika; Ushiba, Junichi; Okano, Hideyuki.

In: Primates, 08.05.2017, p. 1-12.

Research output: Contribution to journalArticle

Ogihara N, Oishi M, Kanai R, Shimada H, Kondo T, Yoshino-Saito K et al. Muscle architectural properties in the common marmoset (Callithrix jacchus). Primates. 2017 May 8;1-12. https://doi.org/10.1007/s10329-017-0608-9
Ogihara, Naomichi ; Oishi, Motoharu ; Kanai, Ryogo ; Shimada, Hikaru ; Kondo, Takahiro ; Yoshino-Saito, Kimika ; Ushiba, Junichi ; Okano, Hideyuki. / Muscle architectural properties in the common marmoset (Callithrix jacchus). In: Primates. 2017 ; pp. 1-12.
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