Muscle fibers actuated by neural signals

Y. Morimoto, M. Kato-Negishi, Hiroaki Onoe, S. Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a method for constructing "neuron-muscle fibers" driven by signals from activated neurons. The fibers consist of stretched muscle fibers covered with highly aligned neurons, and the axons of neurons extend into muscle fibers and form neuromuscular junctions (NMJs). We successfully constructed the neuron-muscle fibers by culturing neural stem cells on stretched muscle fibers; the neural stem cells then differentiated into neurons and connected to muscle cells, forming NMJs. Furthermore, we found that the neuron-muscle fibers contract after treatment of glutamic acid that activates neurons to stimulate the muscle cells. We believe that our neuron-muscle fibers will be not only used as soft-robotic actuators controlled by neuronal signals, but also used in therapeutic and pharmacokinetic assays for NMJ disease models.

Original languageEnglish
Title of host publicationProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pages866-869
Number of pages4
DOIs
Publication statusPublished - 2012
Externally publishedYes
Event2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France
Duration: 2012 Jan 292012 Feb 2

Other

Other2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
CountryFrance
CityParis
Period12/1/2912/2/2

Fingerprint

muscle fibers
neurons
Neurons
Muscle
Fibers
muscle cells
stem cells
Stem cells
Cells
axons
glutamic acid
Pharmacokinetics
robotics
Glutamic Acid
Assays
Robotics
Actuators
actuators

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Condensed Matter Physics
  • Electronic, Optical and Magnetic Materials

Cite this

Morimoto, Y., Kato-Negishi, M., Onoe, H., & Takeuchi, S. (2012). Muscle fibers actuated by neural signals. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 866-869). [6170323] https://doi.org/10.1109/MEMSYS.2012.6170323

Muscle fibers actuated by neural signals. / Morimoto, Y.; Kato-Negishi, M.; Onoe, Hiroaki; Takeuchi, S.

Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2012. p. 866-869 6170323.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Morimoto, Y, Kato-Negishi, M, Onoe, H & Takeuchi, S 2012, Muscle fibers actuated by neural signals. in Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)., 6170323, pp. 866-869, 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012, Paris, France, 12/1/29. https://doi.org/10.1109/MEMSYS.2012.6170323
Morimoto Y, Kato-Negishi M, Onoe H, Takeuchi S. Muscle fibers actuated by neural signals. In Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2012. p. 866-869. 6170323 https://doi.org/10.1109/MEMSYS.2012.6170323
Morimoto, Y. ; Kato-Negishi, M. ; Onoe, Hiroaki ; Takeuchi, S. / Muscle fibers actuated by neural signals. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS). 2012. pp. 866-869
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