Muscle fibers actuated by neural signals

Y. Morimoto, M. Kato-Negishi, H. Onoe, S. Takeuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We propose a method for constructing "neuron-muscle fibers" driven by signals from activated neurons. The fibers consist of stretched muscle fibers covered with highly aligned neurons, and the axons of neurons extend into muscle fibers and form neuromuscular junctions (NMJs). We successfully constructed the neuron-muscle fibers by culturing neural stem cells on stretched muscle fibers; the neural stem cells then differentiated into neurons and connected to muscle cells, forming NMJs. Furthermore, we found that the neuron-muscle fibers contract after treatment of glutamic acid that activates neurons to stimulate the muscle cells. We believe that our neuron-muscle fibers will be not only used as soft-robotic actuators controlled by neuronal signals, but also used in therapeutic and pharmacokinetic assays for NMJ disease models.

Original languageEnglish
Title of host publication2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
Pages866-869
Number of pages4
DOIs
Publication statusPublished - 2012 May 7
Externally publishedYes
Event2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 - Paris, France
Duration: 2012 Jan 292012 Feb 2

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN (Print)1084-6999

Other

Other2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012
CountryFrance
CityParis
Period12/1/2912/2/2

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Morimoto, Y., Kato-Negishi, M., Onoe, H., & Takeuchi, S. (2012). Muscle fibers actuated by neural signals. In 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems, MEMS 2012 (pp. 866-869). [6170323] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMSYS.2012.6170323