Muscle-related polymorphisms (mstn rs1805086 and actn3 rs1815739) are not associated with exceptional longevity in Japanese centenarians

Noriyuki Fuku, Rafael Alis, Thomas Yvert, Hirofumi Zempo, Hisashi Naito, Yukiko Abe, Yasumichi Arai, Haruka Murakami, Motohiko Miyachi, Helios Pareja-Galeano, Enzo Emanuele, Nobuyoshi Hirose, Alejandro Lucia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Myostatin (MSTN) and α-actinin-3 (ACTN3) genes are potentially associated with preservation of muscle mass and oxidative capacity, respectively. To explore the possible role of these genes in exceptional longevity (EL), the allele/genotype frequency distribution of two polymorphisms in MSTN (rs1805086, K153R) and ACTN3 (rs1815739, R577X) was studied in Japanese centenarians of both sexes (n = 742) and healthy controls (n = 814). The rs1805086 R-allele (theoretically associated with muscle mass preservation at the expense of oxidative capacity) was virtually absent in the two groups, where genotype distributions were virtually identical. Likewise, no differences in allele (p = 0.838 (women); p = 0.193 (men); p = 0.587 (both sexes)) or genotype distribution were found between groups for ACTN3 rs1815739 (p = 0.975 (women), p = 0.136 (men), p = 0.752 (both sexes)). Of note, however, the frequency of the rs1805086 R-allele observed here is the lowest been reported to date whereas that of the 'highly oxidative/efficient' rs1815739 XX genotype in Japanese male centenarians (33.3%) or supercentenarians of both sexes (≥110 years) are the highest (32.6%), for a non-American population. No definite conclusions can be inferred in relation to EL owing to its lack of association with both rs1815739 and rs1805086. However, it cannot be excluded that these gene variants could eventually be related to a healthy metabolic phenotype in the Japanese population. Further research might determine if such metabolic profile is among the factors that can potentially predispose these individuals to live longer than Caucasians and what genetic variants might be actually involved.

Original languageEnglish
Article numbere0166605
JournalPLoS One
Volume11
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

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Actinin
Polymorphism
Myostatin
Muscle
Genes
Genotype
genetic polymorphism
alleles
myostatin
Muscles
muscles
gender
genotype
Alleles
genes
Metabolome
Gene Frequency
Population
Phenotype
phenotype

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Muscle-related polymorphisms (mstn rs1805086 and actn3 rs1815739) are not associated with exceptional longevity in Japanese centenarians. / Fuku, Noriyuki; Alis, Rafael; Yvert, Thomas; Zempo, Hirofumi; Naito, Hisashi; Abe, Yukiko; Arai, Yasumichi; Murakami, Haruka; Miyachi, Motohiko; Pareja-Galeano, Helios; Emanuele, Enzo; Hirose, Nobuyoshi; Lucia, Alejandro.

In: PLoS One, Vol. 11, No. 11, e0166605, 01.11.2016.

Research output: Contribution to journalArticle

Fuku, N, Alis, R, Yvert, T, Zempo, H, Naito, H, Abe, Y, Arai, Y, Murakami, H, Miyachi, M, Pareja-Galeano, H, Emanuele, E, Hirose, N & Lucia, A 2016, 'Muscle-related polymorphisms (mstn rs1805086 and actn3 rs1815739) are not associated with exceptional longevity in Japanese centenarians', PLoS One, vol. 11, no. 11, e0166605. https://doi.org/10.1371/journal.pone.0166605
Fuku, Noriyuki ; Alis, Rafael ; Yvert, Thomas ; Zempo, Hirofumi ; Naito, Hisashi ; Abe, Yukiko ; Arai, Yasumichi ; Murakami, Haruka ; Miyachi, Motohiko ; Pareja-Galeano, Helios ; Emanuele, Enzo ; Hirose, Nobuyoshi ; Lucia, Alejandro. / Muscle-related polymorphisms (mstn rs1805086 and actn3 rs1815739) are not associated with exceptional longevity in Japanese centenarians. In: PLoS One. 2016 ; Vol. 11, No. 11.
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abstract = "Myostatin (MSTN) and α-actinin-3 (ACTN3) genes are potentially associated with preservation of muscle mass and oxidative capacity, respectively. To explore the possible role of these genes in exceptional longevity (EL), the allele/genotype frequency distribution of two polymorphisms in MSTN (rs1805086, K153R) and ACTN3 (rs1815739, R577X) was studied in Japanese centenarians of both sexes (n = 742) and healthy controls (n = 814). The rs1805086 R-allele (theoretically associated with muscle mass preservation at the expense of oxidative capacity) was virtually absent in the two groups, where genotype distributions were virtually identical. Likewise, no differences in allele (p = 0.838 (women); p = 0.193 (men); p = 0.587 (both sexes)) or genotype distribution were found between groups for ACTN3 rs1815739 (p = 0.975 (women), p = 0.136 (men), p = 0.752 (both sexes)). Of note, however, the frequency of the rs1805086 R-allele observed here is the lowest been reported to date whereas that of the 'highly oxidative/efficient' rs1815739 XX genotype in Japanese male centenarians (33.3{\%}) or supercentenarians of both sexes (≥110 years) are the highest (32.6{\%}), for a non-American population. No definite conclusions can be inferred in relation to EL owing to its lack of association with both rs1815739 and rs1805086. However, it cannot be excluded that these gene variants could eventually be related to a healthy metabolic phenotype in the Japanese population. Further research might determine if such metabolic profile is among the factors that can potentially predispose these individuals to live longer than Caucasians and what genetic variants might be actually involved.",
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AU - Naito, Hisashi

AU - Abe, Yukiko

AU - Arai, Yasumichi

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