Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation during Muscle Regeneration

Kana Ishii, Nobuharu Suzuki, Yo Mabuchi, Naoki Ito, Naomi Kikura, So Ichiro Fukada, Hideyuki Okano, Shin'Ichi Takeda, Chihiro Akazawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Satellite cells are maintained in an undifferentiated quiescent state, but during muscle regeneration they acquire an activated stage, and initiate to proliferate and differentiate as myoblasts. The transmembrane protein teneurin-4 (Ten-4) is specifically expressed in the quiescent satellite cells; however, its cellular and molecular functions remain unknown. We therefore aimed to elucidate the function of Ten-4 in muscle satellite cells. In the tibialis anterior (TA) muscle of Ten-4-deficient mice, the number and the size of myofibers, as well as the population of satellite cells, were reduced with/without induction of muscle regeneration. Furthermore, we found an accelerated activation of satellite cells in the regenerated Ten-4-deficient TA muscle. The cell culture analysis using primary satellite cells showed that Ten-4 suppressed the progression of myogenic differentiation. Together, our findings revealed that Ten-4 functions as a crucial player in maintaining the quiescence of muscle satellite cells.

Original languageEnglish
Pages (from-to)3017-3027
Number of pages11
JournalStem Cells
Volume33
Issue number10
DOIs
Publication statusPublished - 2015 Oct 1

Keywords

  • Muscle
  • Muscle stem cell
  • Quiescence
  • Regeneration
  • Satellite cell
  • Teneurin-4/Odz4

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Molecular Medicine

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  • Cite this

    Ishii, K., Suzuki, N., Mabuchi, Y., Ito, N., Kikura, N., Fukada, S. I., Okano, H., Takeda, SI., & Akazawa, C. (2015). Muscle Satellite Cell Protein Teneurin-4 Regulates Differentiation during Muscle Regeneration. Stem Cells, 33(10), 3017-3027. https://doi.org/10.1002/stem.2058