Muscle-selective disinhibition of corticomotor representations using a motor imagery-based brain-computer interface

Mitsuaki Takemi, Tsuyoshi Maeda, Yoshihisa Masakado, Hartwig Roman Siebner, Junichi Ushiba

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Bridging between brain activity and machine control, brain-computer interface (BCI) can be employed to activate distributed neural circuits implicated in a specific aspect of motor control. Using a motor imagery-based BCI paradigm, we previously found a disinhibition within the primary motor cortex contralateral to the imagined movement, as evidenced by event-related desynchronization (ERD) of oscillatory cortical activity. Yet it is unclear whether this BCI approach does selectively facilitate corticomotor representations targeted by the imagery. To address this question, we used brain state-dependent transcranial magnetic stimulation while participants performed kinesthetic motor imagery of wrist movements with their right hand and received online visual feedback of the ERD. Single and paired-pulse magnetic stimulation were given to the left primary motor cortex at a low or high level of ERD to assess intracortical excitability. While intracortical facilitation showed no modulation by ERD, short-latency intracortical inhibition was reduced the higher the ERD. Intracortical disinhibition was only found in the agonist muscle targeted by motor imagery at high ERD level, but not in the antagonist muscle. Single pulse motor-evoked potential was also increased the higher the ERD. However, at high ERD level, this facilitatory effect on overall corticospinal excitability was not selective to the agonist muscle. Analogous results were found in two independent experiments, in which participants either performed kinesthetic motor imagery of wrist extension or flexion. Our results showed that motor imagery-based BCI can selectively disinhibit the corticomotor output to the agonist muscle, enabling effector-specific training in patients with motor paralysis.

Original languageEnglish
Pages (from-to)597-605
Number of pages9
JournalNeuroImage
Volume183
DOIs
Publication statusPublished - 2018 Dec 1

Fingerprint

Brain-Computer Interfaces
Imagery (Psychotherapy)
Muscles
Motor Cortex
Wrist
Cortical Synchronization
Motor Evoked Potentials
Sensory Feedback
Transcranial Magnetic Stimulation
Brain
Paralysis
Hand

Keywords

  • Electroencephalogram (EEG)
  • Event-related desynchronization (ERD)
  • Sensorimotor rhythm (SMR)
  • Short-latency intracortical inhibition (SICI)
  • State-dependent
  • Transcranial magnetic stimulation (TMS)

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Muscle-selective disinhibition of corticomotor representations using a motor imagery-based brain-computer interface. / Takemi, Mitsuaki; Maeda, Tsuyoshi; Masakado, Yoshihisa; Siebner, Hartwig Roman; Ushiba, Junichi.

In: NeuroImage, Vol. 183, 01.12.2018, p. 597-605.

Research output: Contribution to journalArticle

Takemi, Mitsuaki ; Maeda, Tsuyoshi ; Masakado, Yoshihisa ; Siebner, Hartwig Roman ; Ushiba, Junichi. / Muscle-selective disinhibition of corticomotor representations using a motor imagery-based brain-computer interface. In: NeuroImage. 2018 ; Vol. 183. pp. 597-605.
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