Mutual dependence of murine fetal cutaneous regeneration and peripheral nerve regeneration

Kazuo Kishi, Kyoji Ohyama, Hiroko Satoh, Yoshiaki Kubota, Takara Tanaka, Nobuaki Imanishi, Hideo Nakajima, Kohki Kawamura, Tatsuo Nakajima

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Mammalian fetal cutaneous wounds made at certain developmental stages show complete regeneration. It is reported that wound healing in both adult and fetal skin is disrupted by denervation. Furthermore, fetal cutaneous regeneration has unique aspects such as epidermal wrinkle texture regeneration and dermal regeneration that depend on developmental stage. Therefore, we have examined the relationship of fetal cutaneous regeneration with denervation. We made cutaneous wounds on fetal mice at various developmental time points including embryonic days (E)13, E15, and E17, and compared the regenerating patterns of peripheral nerves in the skin. We found that when the fetuses are wounded at an early stage of development, peripheral nerves regenerate quicker than at later stages of development when peripheral nerve regeneration is delayed. Next, we denervated the intercostal nerves and made wounds at the denervated sites on E13 and E15. We found that epidermal wrinkling and dermal regeneration were disrupted by denervation. These findings indicate that components of fetal cutaneous regeneration and peripheral nerve regeneration are mutually dependent.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalWound Repair and Regeneration
Volume14
Issue number1
DOIs
Publication statusPublished - 2006 Jan

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Nerve Regeneration
Peripheral Nerves
Regeneration
Skin
Denervation
Wounds and Injuries
Intercostal Nerves
Wound Healing
Fetus

ASJC Scopus subject areas

  • Dermatology
  • Surgery

Cite this

Mutual dependence of murine fetal cutaneous regeneration and peripheral nerve regeneration. / Kishi, Kazuo; Ohyama, Kyoji; Satoh, Hiroko; Kubota, Yoshiaki; Tanaka, Takara; Imanishi, Nobuaki; Nakajima, Hideo; Kawamura, Kohki; Nakajima, Tatsuo.

In: Wound Repair and Regeneration, Vol. 14, No. 1, 01.2006, p. 91-99.

Research output: Contribution to journalArticle

Kishi, Kazuo ; Ohyama, Kyoji ; Satoh, Hiroko ; Kubota, Yoshiaki ; Tanaka, Takara ; Imanishi, Nobuaki ; Nakajima, Hideo ; Kawamura, Kohki ; Nakajima, Tatsuo. / Mutual dependence of murine fetal cutaneous regeneration and peripheral nerve regeneration. In: Wound Repair and Regeneration. 2006 ; Vol. 14, No. 1. pp. 91-99.
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