Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40+ CD4+ T cells

Ai Kotani, Atsushi Takahashi, Hikari Koga, Rinpei Morita, Hidenao Fukuyama, Tatsuo Ichinohe, Takayuki Ishikawa, Toshiyuki Hori, Takashi Uchiyama

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A patient who developed myasthenia gravis (MG) 25 months after allogeneic bone marrow transplant was immunologically analyzed. OX40+ CD4+ T cells in the peripheral blood prominently increased one month before the onset of MG. CD4/CD8 ratios, usually abnormally inverted in patients with chronic graft-vs.-host disease (cGVHD), showed pseudonormalization during the course of MG. We succeeded in uneventful rapid tapering of prednisolone (PSL) using mycophenolate mofetil (MMF). Monitoring of OX40+ CD4+ T cells supported the tapering of PSL and MMF as a marker of cGVHD activity. This case suggested the utility of MMF and monitoring of OX40+ CD4+ T cells in the management of cGVHD-associated autoimmune diseases.

Original languageEnglish
Pages (from-to)318-320
Number of pages3
JournalEuropean Journal of Haematology
Volume69
Issue number5-6
DOIs
Publication statusPublished - 2002 Nov 1

Keywords

  • Chronic graft-vs.-host disease
  • Myasthenia gravis
  • Mycophenolate mofetil
  • OX40

ASJC Scopus subject areas

  • Hematology

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