Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40+ CD4+ T cells

Ai Kotani; Atsushi Takahashi; Hikari Koga; Rinpei Morita; Hidenao Fukuyama; Tatsuo Ichinohe; Takayuki Ishikawa; Toshiyuki Hori; Takashi Uchiyama

doi:10.1034/j.1600-0609.2002.02789.x

Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40⁺ CD4⁺ T cells

Ai Kotani, Atsushi Takahashi, Hikari Koga, Rinpei Morita, Hidenao Fukuyama, Tatsuo Ichinohe, Takayuki Ishikawa, Toshiyuki Hori, Takashi Uchiyama

Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A patient who developed myasthenia gravis (MG) 25 months after allogeneic bone marrow transplant was immunologically analyzed. OX40⁺ CD4⁺ T cells in the peripheral blood prominently increased one month before the onset of MG. CD4/CD8 ratios, usually abnormally inverted in patients with chronic graft-vs.-host disease (cGVHD), showed pseudonormalization during the course of MG. We succeeded in uneventful rapid tapering of prednisolone (PSL) using mycophenolate mofetil (MMF). Monitoring of OX40⁺ CD4⁺ T cells supported the tapering of PSL and MMF as a marker of cGVHD activity. This case suggested the utility of MMF and monitoring of OX40⁺ CD4⁺ T cells in the management of cGVHD-associated autoimmune diseases.

Original language	English
Pages (from-to)	318-320
Number of pages	3
Journal	European Journal of Haematology
Volume	69
Issue number	5-6
DOIs	https://doi.org/10.1034/j.1600-0609.2002.02789.x
Publication status	Published - 2002 Nov 1

Keywords

Chronic graft-vs.-host disease
Myasthenia gravis
Mycophenolate mofetil
OX40

ASJC Scopus subject areas

Hematology

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Kotani, A., Takahashi, A., Koga, H., Morita, R., Fukuyama, H., Ichinohe, T., Ishikawa, T., Hori, T., & Uchiyama, T. (2002). Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40⁺ CD4⁺ T cells. European Journal of Haematology, 69(5-6), 318-320. https://doi.org/10.1034/j.1600-0609.2002.02789.x

Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40⁺ CD4⁺ T cells. / Kotani, Ai; Takahashi, Atsushi; Koga, Hikari; Morita, Rinpei; Fukuyama, Hidenao; Ichinohe, Tatsuo; Ishikawa, Takayuki; Hori, Toshiyuki; Uchiyama, Takashi.

In: European Journal of Haematology, Vol. 69, No. 5-6, 01.11.2002, p. 318-320.

Research output: Contribution to journal › Article › peer-review

Kotani, A, Takahashi, A, Koga, H, Morita, R, Fukuyama, H, Ichinohe, T, Ishikawa, T, Hori, T & Uchiyama, T 2002, 'Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40⁺ CD4⁺ T cells', European Journal of Haematology, vol. 69, no. 5-6, pp. 318-320. https://doi.org/10.1034/j.1600-0609.2002.02789.x

Kotani, Ai ; Takahashi, Atsushi ; Koga, Hikari ; Morita, Rinpei ; Fukuyama, Hidenao ; Ichinohe, Tatsuo ; Ishikawa, Takayuki ; Hori, Toshiyuki ; Uchiyama, Takashi. / Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40⁺ CD4⁺ T cells. In: European Journal of Haematology. 2002 ; Vol. 69, No. 5-6. pp. 318-320.

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abstract = "A patient who developed myasthenia gravis (MG) 25 months after allogeneic bone marrow transplant was immunologically analyzed. OX40+ CD4+ T cells in the peripheral blood prominently increased one month before the onset of MG. CD4/CD8 ratios, usually abnormally inverted in patients with chronic graft-vs.-host disease (cGVHD), showed pseudonormalization during the course of MG. We succeeded in uneventful rapid tapering of prednisolone (PSL) using mycophenolate mofetil (MMF). Monitoring of OX40+ CD4+ T cells supported the tapering of PSL and MMF as a marker of cGVHD activity. This case suggested the utility of MMF and monitoring of OX40+ CD4+ T cells in the management of cGVHD-associated autoimmune diseases.",

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AU - Morita, Rinpei

AU - Fukuyama, Hidenao

AU - Ichinohe, Tatsuo

AU - Ishikawa, Takayuki

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