Abstract
A patient who developed myasthenia gravis (MG) 25 months after allogeneic bone marrow transplant was immunologically analyzed. OX40+ CD4+ T cells in the peripheral blood prominently increased one month before the onset of MG. CD4/CD8 ratios, usually abnormally inverted in patients with chronic graft-vs.-host disease (cGVHD), showed pseudonormalization during the course of MG. We succeeded in uneventful rapid tapering of prednisolone (PSL) using mycophenolate mofetil (MMF). Monitoring of OX40+ CD4+ T cells supported the tapering of PSL and MMF as a marker of cGVHD activity. This case suggested the utility of MMF and monitoring of OX40+ CD4+ T cells in the management of cGVHD-associated autoimmune diseases.
Original language | English |
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Pages (from-to) | 318-320 |
Number of pages | 3 |
Journal | European Journal of Haematology |
Volume | 69 |
Issue number | 5-6 |
DOIs | |
Publication status | Published - 2002 Nov 1 |
Keywords
- Chronic graft-vs.-host disease
- Myasthenia gravis
- Mycophenolate mofetil
- OX40
ASJC Scopus subject areas
- Hematology