Abstract
A patient who developed myasthenia gravis (MG) 25 months after allogeneic bone marrow transplant was immunologically analyzed. OX40+ CD4+ T cells in the peripheral blood prominently increased one month before the onset of MG. CD4/CD8 ratios, usually abnormally inverted in patients with chronic graft-vs.-host disease (cGVHD), showed pseudonormalization during the course of MG. We succeeded in uneventful rapid tapering of prednisolone (PSL) using mycophenolate mofetil (MMF). Monitoring of OX40+ CD4+ T cells supported the tapering of PSL and MMF as a marker of cGVHD activity. This case suggested the utility of MMF and monitoring of OX40+ CD4+ T cells in the management of cGVHD-associated autoimmune diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 318-320 |
| Number of pages | 3 |
| Journal | European Journal of Haematology |
| Volume | 69 |
| Issue number | 5-6 |
| DOIs | |
| Publication status | Published - 2002 Nov |
| Externally published | Yes |
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Keywords
- Chronic graft-vs.-host disease
- Myasthenia gravis
- Mycophenolate mofetil
- OX40
ASJC Scopus subject areas
- Hematology
Cite this
Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40+ CD4+ T cells. / Kotani, Ai; Takahashi, Atsushi; Koga, Hikari; Morita, Rinpei; Fukuyama, Hidenao; Ichinohe, Tatsuo; Ishikawa, Takayuki; Hori, Toshiyuki; Uchiyama, Takashi.
In: European Journal of Haematology, Vol. 69, No. 5-6, 11.2002, p. 318-320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40+ CD4+ T cells
AU - Kotani, Ai
AU - Takahashi, Atsushi
AU - Koga, Hikari
AU - Morita, Rinpei
AU - Fukuyama, Hidenao
AU - Ichinohe, Tatsuo
AU - Ishikawa, Takayuki
AU - Hori, Toshiyuki
AU - Uchiyama, Takashi
PY - 2002/11
Y1 - 2002/11
N2 - A patient who developed myasthenia gravis (MG) 25 months after allogeneic bone marrow transplant was immunologically analyzed. OX40+ CD4+ T cells in the peripheral blood prominently increased one month before the onset of MG. CD4/CD8 ratios, usually abnormally inverted in patients with chronic graft-vs.-host disease (cGVHD), showed pseudonormalization during the course of MG. We succeeded in uneventful rapid tapering of prednisolone (PSL) using mycophenolate mofetil (MMF). Monitoring of OX40+ CD4+ T cells supported the tapering of PSL and MMF as a marker of cGVHD activity. This case suggested the utility of MMF and monitoring of OX40+ CD4+ T cells in the management of cGVHD-associated autoimmune diseases.
AB - A patient who developed myasthenia gravis (MG) 25 months after allogeneic bone marrow transplant was immunologically analyzed. OX40+ CD4+ T cells in the peripheral blood prominently increased one month before the onset of MG. CD4/CD8 ratios, usually abnormally inverted in patients with chronic graft-vs.-host disease (cGVHD), showed pseudonormalization during the course of MG. We succeeded in uneventful rapid tapering of prednisolone (PSL) using mycophenolate mofetil (MMF). Monitoring of OX40+ CD4+ T cells supported the tapering of PSL and MMF as a marker of cGVHD activity. This case suggested the utility of MMF and monitoring of OX40+ CD4+ T cells in the management of cGVHD-associated autoimmune diseases.
KW - Chronic graft-vs.-host disease
KW - Myasthenia gravis
KW - Mycophenolate mofetil
KW - OX40
UR - http://www.scopus.com/inward/record.url?scp=0036867536&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036867536&partnerID=8YFLogxK
U2 - 10.1034/j.1600-0609.2002.02789.x
DO - 10.1034/j.1600-0609.2002.02789.x
M3 - Article
C2 - 12460238
AN - SCOPUS:0036867536
VL - 69
SP - 318
EP - 320
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 5-6
ER -