Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40+ CD4+ T cells

Ai Kotani, Atsushi Takahashi, Hikari Koga, Rinpei Morita, Hidenao Fukuyama, Tatsuo Ichinohe, Takayuki Ishikawa, Toshiyuki Hori, Takashi Uchiyama

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A patient who developed myasthenia gravis (MG) 25 months after allogeneic bone marrow transplant was immunologically analyzed. OX40+ CD4+ T cells in the peripheral blood prominently increased one month before the onset of MG. CD4/CD8 ratios, usually abnormally inverted in patients with chronic graft-vs.-host disease (cGVHD), showed pseudonormalization during the course of MG. We succeeded in uneventful rapid tapering of prednisolone (PSL) using mycophenolate mofetil (MMF). Monitoring of OX40+ CD4+ T cells supported the tapering of PSL and MMF as a marker of cGVHD activity. This case suggested the utility of MMF and monitoring of OX40+ CD4+ T cells in the management of cGVHD-associated autoimmune diseases.

Original languageEnglish
Pages (from-to)318-320
Number of pages3
JournalEuropean Journal of Haematology
Volume69
Issue number5-6
DOIs
Publication statusPublished - 2002 Nov
Externally publishedYes

Fingerprint

Mycophenolic Acid
Myasthenia Gravis
Homologous Transplantation
Bone Marrow Transplantation
Prednisolone
T-Lymphocytes
Transplants
CD4-CD8 Ratio
Autoimmune Diseases
Bone Marrow

Keywords

  • Chronic graft-vs.-host disease
  • Myasthenia gravis
  • Mycophenolate mofetil
  • OX40

ASJC Scopus subject areas

  • Hematology

Cite this

Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40+ CD4+ T cells. / Kotani, Ai; Takahashi, Atsushi; Koga, Hikari; Morita, Rinpei; Fukuyama, Hidenao; Ichinohe, Tatsuo; Ishikawa, Takayuki; Hori, Toshiyuki; Uchiyama, Takashi.

In: European Journal of Haematology, Vol. 69, No. 5-6, 11.2002, p. 318-320.

Research output: Contribution to journalArticle

Kotani, Ai ; Takahashi, Atsushi ; Koga, Hikari ; Morita, Rinpei ; Fukuyama, Hidenao ; Ichinohe, Tatsuo ; Ishikawa, Takayuki ; Hori, Toshiyuki ; Uchiyama, Takashi. / Myasthenia gravis after allogeneic bone marrow transplantation treated with mycophenolate mofetil monitored by peripheral blood OX40+ CD4+ T cells. In: European Journal of Haematology. 2002 ; Vol. 69, No. 5-6. pp. 318-320.
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abstract = "A patient who developed myasthenia gravis (MG) 25 months after allogeneic bone marrow transplant was immunologically analyzed. OX40+ CD4+ T cells in the peripheral blood prominently increased one month before the onset of MG. CD4/CD8 ratios, usually abnormally inverted in patients with chronic graft-vs.-host disease (cGVHD), showed pseudonormalization during the course of MG. We succeeded in uneventful rapid tapering of prednisolone (PSL) using mycophenolate mofetil (MMF). Monitoring of OX40+ CD4+ T cells supported the tapering of PSL and MMF as a marker of cGVHD activity. This case suggested the utility of MMF and monitoring of OX40+ CD4+ T cells in the management of cGVHD-associated autoimmune diseases.",
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AU - Morita, Rinpei

AU - Fukuyama, Hidenao

AU - Ichinohe, Tatsuo

AU - Ishikawa, Takayuki

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