Mycobacterium kansasii lung infection associated with myelofibrosis - A case refractory to treatment with antitubercular agents

A. Umeda, K. Asano, A. Kawai, H. Nakamura, H. Fujita, Masaaki Mori, K. Yamaguchi, M. Kanazawa

Research output: Contribution to journalArticle

Abstract

A case of Mycobacterium kanasasii lung infection associated with myelofibrosis is reported. A 32-year-old woman was admitted to Keio University Hospital because of fever. One year before admission, a diagnosis of myelofibrosis was made at another hospital. The initial chest X-ray film showed bilateral diffuse infiltrative shadows and right hilar enlargement. Sputum cultures yielded Mycobacterium kansasii on 3 occasions. A fever of 38°C or higher persisted for about 4 months despite the use of antitubercular agents, including INH, RFP, SM, and PZA. During the course of treatment, the hilar and mediastinal lymph node enlargement became more severe, and this was followed by calcification of the nodes. The fever and chest X-ray findings improved in response to the addition of treatment with EB, Ofloxacin, TH, and an increase in the doses of INH (from 300 to 500 mg/day) and RFP (from 450 to 600 mg/day). The patient was discharged 14 months after admission. It is rare especially in Japan for a Mycobacterium kansasii lung infection (not disseminated) to persist in spite of treatment with antitubercular drugs, including RFP or TH. The response to treatment may have been impaired by an immunological disorder associated with the myelofibrosis.

Original languageEnglish
Pages (from-to)1170-1174
Number of pages5
JournalJapanese Journal of Thoracic Diseases
Volume32
Issue number12
Publication statusPublished - 1994

Fingerprint

Mycobacterium kansasii
Antitubercular Agents
Primary Myelofibrosis
Lung
Fever
Infection
Thorax
X-Ray Film
Ofloxacin
Therapeutics
Mycobacterium
Sputum
Japan
Lymph Nodes
X-Rays

Keywords

  • atypical mycobacterial infection
  • Mycobacterium kansasii
  • myelofibrosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Mycobacterium kansasii lung infection associated with myelofibrosis - A case refractory to treatment with antitubercular agents. / Umeda, A.; Asano, K.; Kawai, A.; Nakamura, H.; Fujita, H.; Mori, Masaaki; Yamaguchi, K.; Kanazawa, M.

In: Japanese Journal of Thoracic Diseases, Vol. 32, No. 12, 1994, p. 1170-1174.

Research output: Contribution to journalArticle

Umeda, A, Asano, K, Kawai, A, Nakamura, H, Fujita, H, Mori, M, Yamaguchi, K & Kanazawa, M 1994, 'Mycobacterium kansasii lung infection associated with myelofibrosis - A case refractory to treatment with antitubercular agents', Japanese Journal of Thoracic Diseases, vol. 32, no. 12, pp. 1170-1174.
Umeda, A. ; Asano, K. ; Kawai, A. ; Nakamura, H. ; Fujita, H. ; Mori, Masaaki ; Yamaguchi, K. ; Kanazawa, M. / Mycobacterium kansasii lung infection associated with myelofibrosis - A case refractory to treatment with antitubercular agents. In: Japanese Journal of Thoracic Diseases. 1994 ; Vol. 32, No. 12. pp. 1170-1174.
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