MyD88 ptotects from lethal encephalitis during infection with vesicular stomatitis virus

Karl Lang, Alexander A. Navarini, Mike Recher, Philipp A. Lang, Mathias Heikenwalder, Barbara Stecher, Andreas Bergthaler, Bernhard Odermatt, Shizuo Akira, Kenya Honda, Hans Hengartner, Rolf M. Zinkernagel

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25 Citations (Scopus)

Abstract

MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88-/- mice. We found an increased susceptibility to VSV in myd88-/- mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88-/- mice correlated with impaired recruitment of immune cells to the site of infection. in the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.

Original languageEnglish
Pages (from-to)2434-2440
Number of pages7
JournalEuropean Journal of Immunology
Volume37
Issue number9
DOIs
Publication statusPublished - 2007 Sep

Keywords

  • Inflammation
  • Toll-like receptor
  • Vesicular stomatitis
  • Virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Lang, K., Navarini, A. A., Recher, M., Lang, P. A., Heikenwalder, M., Stecher, B., Bergthaler, A., Odermatt, B., Akira, S., Honda, K., Hengartner, H., & Zinkernagel, R. M. (2007). MyD88 ptotects from lethal encephalitis during infection with vesicular stomatitis virus. European Journal of Immunology, 37(9), 2434-2440. https://doi.org/10.1002/eji.200737310