MyD88 ptotects from lethal encephalitis during infection with vesicular stomatitis virus

Karl Lang; Alexander A. Navarini; Mike Recher; Philipp A. Lang; Mathias Heikenwalder; Barbara Stecher; Andreas Bergthaler; Bernhard Odermatt; Shizuo Akira; Kenya Honda; Hans Hengartner; Rolf M. Zinkernagel

doi:10.1002/eji.200737310

MyD88 ptotects from lethal encephalitis during infection with vesicular stomatitis virus

Karl Lang, Alexander A. Navarini, Mike Recher, Philipp A. Lang, Mathias Heikenwalder, Barbara Stecher, Andreas Bergthaler, Bernhard Odermatt, Shizuo Akira, Kenya Honda, Hans Hengartner, Rolf M. Zinkernagel

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88^-/- mice. We found an increased susceptibility to VSV in myd88^-/- mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88^-/- mice correlated with impaired recruitment of immune cells to the site of infection. in the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.

Original language	English
Pages (from-to)	2434-2440
Number of pages	7
Journal	European Journal of Immunology
Volume	37
Issue number	9
DOIs	https://doi.org/10.1002/eji.200737310
Publication status	Published - 2007 Sep
Externally published	Yes

Keywords

Inflammation
Toll-like receptor
Vesicular stomatitis
Virus

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1002/eji.200737310

Cite this

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title = "MyD88 ptotects from lethal encephalitis during infection with vesicular stomatitis virus",

abstract = "MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88-/- mice. We found an increased susceptibility to VSV in myd88-/- mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88-/- mice correlated with impaired recruitment of immune cells to the site of infection. in the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.",

keywords = "Inflammation, Toll-like receptor, Vesicular stomatitis, Virus",

author = "Karl Lang and Navarini, {Alexander A.} and Mike Recher and Lang, {Philipp A.} and Mathias Heikenwalder and Barbara Stecher and Andreas Bergthaler and Bernhard Odermatt and Shizuo Akira and Kenya Honda and Hans Hengartner and Zinkernagel, {Rolf M.}",

year = "2007",

month = sep,

doi = "10.1002/eji.200737310",

language = "English",

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AU - Lang, Karl

AU - Navarini, Alexander A.

AU - Recher, Mike

AU - Lang, Philipp A.

AU - Heikenwalder, Mathias

AU - Stecher, Barbara

AU - Bergthaler, Andreas

AU - Odermatt, Bernhard

AU - Akira, Shizuo

AU - Honda, Kenya

AU - Hengartner, Hans

AU - Zinkernagel, Rolf M.

PY - 2007/9

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AB - MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88-/- mice. We found an increased susceptibility to VSV in myd88-/- mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88-/- mice correlated with impaired recruitment of immune cells to the site of infection. in the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.

KW - Inflammation

KW - Toll-like receptor

KW - Vesicular stomatitis

KW - Virus

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MyD88 ptotects from lethal encephalitis during infection with vesicular stomatitis virus

Abstract

Keywords

ASJC Scopus subject areas

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