Abstract
Autologous bone marrow transplantation (ABMT) anti peripheral blood stem cell transplantation (PBSCT) are increasingly used to support high dose chemotherapy for solid tumors of childhood. In this review we described practical aspects of myeloablative chemotherapy rescued by ABMT, PBSCT or combination of ABMT and PBSCT for the treatment of children with high risk solid tumor, involving our experiences in 15 cases. Indication, method of harvesting bone marrow and peripheral blood stem cells, cryopreservation, transplantation, selection of antineoplastic agents for preconditioning, nutritional and G-CSF support, engraftment and outcomes for prognosis were discussed. In comparing the engraftment of stem cells between ABMT and PBSCT, the accerelation of platelet and erythrocyte recovery is less impressive, although there is a tendency to more rapid recovery of granulocyte in PBSCT group. The outcomes are distinctly improved only in patients who showed complete remission after induction chemotherapy, radiation and surgical excision. A better prognosis will be confered especially in neuroblastoma and entities of small round cell tumor. It is noteworthy that relapses can occur as distant metastasis considerable years after complete clinical remission. This may be largely contributed by contaminated malignant cells in both harvested bone marrow anti peripheral blood stem cells. There is no significant difference between the relapse rates after ABMT and PBSCT.
| Original language | English |
|---|---|
| Pages (from-to) | 1762-1770 |
| Number of pages | 9 |
| Journal | Japanese Journal of Cancer and Chemotherapy |
| Volume | 22 |
| Issue number | 12 |
| Publication status | Published - 1995 |
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Keywords
- Autologous bone marrow transplantation
- Myeloablative chemotherapy
- Pediatric solid tumors
- Peripheral blood stem cell transplantation
ASJC Scopus subject areas
- Cancer Research
- Pharmacology
Cite this
Myeloablative chemotherapy with autologous bone marrow and/or peripheral blood stem cell transplantation in children with high risk solid tumor. / Endo, M.; Tanosaki, Ryuji.
In: Japanese Journal of Cancer and Chemotherapy, Vol. 22, No. 12, 1995, p. 1762-1770.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Myeloablative chemotherapy with autologous bone marrow and/or peripheral blood stem cell transplantation in children with high risk solid tumor
AU - Endo, M.
AU - Tanosaki, Ryuji
PY - 1995
Y1 - 1995
N2 - Autologous bone marrow transplantation (ABMT) anti peripheral blood stem cell transplantation (PBSCT) are increasingly used to support high dose chemotherapy for solid tumors of childhood. In this review we described practical aspects of myeloablative chemotherapy rescued by ABMT, PBSCT or combination of ABMT and PBSCT for the treatment of children with high risk solid tumor, involving our experiences in 15 cases. Indication, method of harvesting bone marrow and peripheral blood stem cells, cryopreservation, transplantation, selection of antineoplastic agents for preconditioning, nutritional and G-CSF support, engraftment and outcomes for prognosis were discussed. In comparing the engraftment of stem cells between ABMT and PBSCT, the accerelation of platelet and erythrocyte recovery is less impressive, although there is a tendency to more rapid recovery of granulocyte in PBSCT group. The outcomes are distinctly improved only in patients who showed complete remission after induction chemotherapy, radiation and surgical excision. A better prognosis will be confered especially in neuroblastoma and entities of small round cell tumor. It is noteworthy that relapses can occur as distant metastasis considerable years after complete clinical remission. This may be largely contributed by contaminated malignant cells in both harvested bone marrow anti peripheral blood stem cells. There is no significant difference between the relapse rates after ABMT and PBSCT.
AB - Autologous bone marrow transplantation (ABMT) anti peripheral blood stem cell transplantation (PBSCT) are increasingly used to support high dose chemotherapy for solid tumors of childhood. In this review we described practical aspects of myeloablative chemotherapy rescued by ABMT, PBSCT or combination of ABMT and PBSCT for the treatment of children with high risk solid tumor, involving our experiences in 15 cases. Indication, method of harvesting bone marrow and peripheral blood stem cells, cryopreservation, transplantation, selection of antineoplastic agents for preconditioning, nutritional and G-CSF support, engraftment and outcomes for prognosis were discussed. In comparing the engraftment of stem cells between ABMT and PBSCT, the accerelation of platelet and erythrocyte recovery is less impressive, although there is a tendency to more rapid recovery of granulocyte in PBSCT group. The outcomes are distinctly improved only in patients who showed complete remission after induction chemotherapy, radiation and surgical excision. A better prognosis will be confered especially in neuroblastoma and entities of small round cell tumor. It is noteworthy that relapses can occur as distant metastasis considerable years after complete clinical remission. This may be largely contributed by contaminated malignant cells in both harvested bone marrow anti peripheral blood stem cells. There is no significant difference between the relapse rates after ABMT and PBSCT.
KW - Autologous bone marrow transplantation
KW - Myeloablative chemotherapy
KW - Pediatric solid tumors
KW - Peripheral blood stem cell transplantation
UR - http://www.scopus.com/inward/record.url?scp=0028877427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028877427&partnerID=8YFLogxK
M3 - Article
C2 - 7574807
AN - SCOPUS:0028877427
VL - 22
SP - 1762
EP - 1770
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 12
ER -