Myoinositol to Total Choline Ratio in Glioblastomas as a Potential Prognostic Factor in Preoperative Magnetic Resonance Spectroscopy

Masanobu Kumon, Shunsuke Nakae, Kazuhiro Murayama, Takema Kato, Shigeo Ohba, Joji Inamasu, Seiji Yamada, Masato Abe, Hikaru Sasaki, Yoshiharu Ohno, Mitsuhiro Hasegawa, Hiroki Kurahashi, Yuichi Hirose

Research output: Contribution to journalArticlepeer-review

Abstract

Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors tend to be pathologically diagnosed as glioblastomas (GBMs). We previously reported that myoinositol to total choline (Ins/Cho) ratio in GBMs on magnetic resonance (MR) spectroscopy was significantly lower than that in IDH-mutant gliomas. We then hypothesized that a low Ins/Cho ratio is a poor prognosis factor in patients with GBMs, IDH-wild-type. In the present study, we calculated the Ins/Cho ratios of patients with GBMs and investigated their progression-free survival (PFS) and overall survival (OS) to determine their utility as prognostic marker. We classified patients with GBMs harboring wild-type IDH (n = 27) into two groups based on the Ins/Cho ratio, and compared patient backgrounds, pathological findings, PFS, OS, and copy number aberrations between the high and low Ins/Cho groups. Patients with GBMs in the low Ins/Cho ratio group indicated shorter PFS (P = 0.021) and OS (P = 0.048) than those in the high Ins/Cho group. Multivariate analysis demonstrated that the Ins/Cho ratio was significantly correlated with PFS (hazard ratio 0.24, P = 0.028). In conclusion, the preoperative Ins/Cho ratio can be used as a novel potential prognostic factor for GBM, IDH-wild-type.

Original languageEnglish
Pages (from-to)453-460
Number of pages8
JournalNeurologia medico-chirurgica
Volume61
Issue number8
DOIs
Publication statusPublished - 2021 Aug 15

Keywords

  • glioblastoma
  • magnetic resonance spectroscopy
  • myoinositol

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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