Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome.

Shigeaki Suzuki, Yukiko K. Hayashi, Masataka Kuwana, Rie Tsuburaya, Norihiro Suzuki, Ichizo Nishino

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

To characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy. Case series. Keio University Hospitals and National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. We reviewed clinical features of 27 patients with anti-SRP myopathy and analyzed disease progression and neurological outcome. Anti-SRP antibodies in serum were detected by RNA immunoprecipitation assay using extracts of K562 cells. Of the 27 patients, 5 (19%) showed chronic progressive muscle weakness as well as atrophy of limbs and trunk muscles from a younger age with more severe neurological outcomes compared with the other 22 patients(81%) with the subacute form. A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits.

Original languageEnglish
Pages (from-to)728-732
Number of pages5
JournalArchives of Neurology
Volume69
Issue number6
Publication statusPublished - 2012 Jun

Fingerprint

Signal Recognition Particle
Muscular Diseases
Disease Progression
Antibodies
Muscular Atrophy
K562 Cells
Tokyo
Muscle Weakness
Neurology
Neurosciences
Immunoprecipitation
Psychiatry
Japan
Extremities
Particle
Progression
RNA
Muscles
Serum

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Suzuki, S., Hayashi, Y. K., Kuwana, M., Tsuburaya, R., Suzuki, N., & Nishino, I. (2012). Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome. Archives of Neurology, 69(6), 728-732.

Myopathy associated with antibodies to signal recognition particle : disease progression and neurological outcome. / Suzuki, Shigeaki; Hayashi, Yukiko K.; Kuwana, Masataka; Tsuburaya, Rie; Suzuki, Norihiro; Nishino, Ichizo.

In: Archives of Neurology, Vol. 69, No. 6, 06.2012, p. 728-732.

Research output: Contribution to journalArticle

Suzuki, S, Hayashi, YK, Kuwana, M, Tsuburaya, R, Suzuki, N & Nishino, I 2012, 'Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome.', Archives of Neurology, vol. 69, no. 6, pp. 728-732.
Suzuki, Shigeaki ; Hayashi, Yukiko K. ; Kuwana, Masataka ; Tsuburaya, Rie ; Suzuki, Norihiro ; Nishino, Ichizo. / Myopathy associated with antibodies to signal recognition particle : disease progression and neurological outcome. In: Archives of Neurology. 2012 ; Vol. 69, No. 6. pp. 728-732.
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