Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome.

Shigeaki Suzuki, Yukiko K. Hayashi, Masataka Kuwana, Rie Tsuburaya, Norihiro Suzuki, Ichizo Nishino

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

To characterize the clinical course of myopathy associated with antibodies to signal recognition particle (SRP), or anti-SRP myopathy. Case series. Keio University Hospitals and National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. We reviewed clinical features of 27 patients with anti-SRP myopathy and analyzed disease progression and neurological outcome. Anti-SRP antibodies in serum were detected by RNA immunoprecipitation assay using extracts of K562 cells. Of the 27 patients, 5 (19%) showed chronic progressive muscle weakness as well as atrophy of limbs and trunk muscles from a younger age with more severe neurological outcomes compared with the other 22 patients(81%) with the subacute form. A subset of patients with anti-SRP myopathy can show a chronic progressive form associated with severe clinical deficits.

Original languageEnglish
Pages (from-to)728-732
Number of pages5
JournalArchives of neurology
Volume69
Issue number6
Publication statusPublished - 2012 Jun

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Myopathy associated with antibodies to signal recognition particle: disease progression and neurological outcome.'. Together they form a unique fingerprint.

Cite this