We describe 2 patients with myositis and interstitial lung disease with the autoantibody to Wa antigen, a 48-kDa transfer RNA-related protein. In contrast to the previous description of anti-Wa antibody, our patients lacked systemic sclerosis-related features, but had clinical features consistent with those associated with antibodies to aminoacyl-transfer RNA synthetases. The difference in clinical presentation between our patients and patients with systemic sclerosis may be explained by recognition of different epitopes on the Wa antigen.
|Number of pages||4|
|Journal||Journal of Rheumatology|
|Publication status||Published - 2000 Dec 2|
- Interstitial lung disease
- Transfer RNA
ASJC Scopus subject areas
- Immunology and Allergy