Myositis-specific autoantibodies and their clinical significance

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The idiopathic inflammatory myopathies polymyositis (PM) and dermatomyositis (DM) have historically been defined using broad clinical and pathological criteria. These conditions affect both adults and children with clinical features including muscle weakness, skin disease, internal organ involvement, and an association with cancer in adults. Using a clinical-serological approach, PM and DM can be defined into more homogeneous subsets. In recent years, myositis-specific autoantibodies (MSAs) have been better characterized and include autoantibodies to the signal-recognition particle and aminoacyl tRNA-synthetase enzymes. In addition, clinically significant novel autoantibodies - anti-p155/p140, anti-CADM-140, and others - have been described in the disease spectrum. MSAs are directed against cytoplasmic or nuclear components involved in key regulatory intracellular processes including protein synthesis, translocation, and transcription. The striking association between unique serological profiles and distinct clinical phenotypes suggests that target autoantigens may play a role in disease induction and propagation. This review reports recent progress in myositis-specific autoantigens, particularly their clinical significance.

Original languageEnglish
Pages (from-to)1197-1203
Number of pages7
JournalBrain and Nerve
Volume63
Issue number11
Publication statusPublished - 2011 Nov 1

Fingerprint

Myositis
Autoantibodies
Dermatomyositis
Autoantigens
Signal Recognition Particle
Amino Acyl-tRNA Synthetases
Muscle Weakness
Protein Transport
Skin Diseases
Phenotype
Enzymes
Neoplasms

Keywords

  • Dermatomyositis
  • Inflammatory myopathy
  • Myositis-specific autoantibodies
  • Polymyositis
  • Signal recognition particle

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Myositis-specific autoantibodies and their clinical significance. / Suzuki, Shigeaki.

In: Brain and Nerve, Vol. 63, No. 11, 01.11.2011, p. 1197-1203.

Research output: Contribution to journalArticle

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