Nadir Aldosterone Levels after Confirmatory Tests Are Correlated with Left Ventricular Hypertrophy in Primary Aldosteronism

Youichi Ohno, Masakatsu Sone, Nobuya Inagaki, Akiyuki Kawashima, Yoshiyu Takeda, Takashi Yoneda, Isao Kurihara, Hiroshi Itoh, Mika Tsuiki, Takamasa Ichijo, Takuyuki Katabami, Norio Wada, Ryuichi Sakamoto, Yoshihiro Ogawa, Takanobu Yoshimoto, Tetsuya Yamada, Junji Kawashima, Yuichi Matsuda, Hiroki Kobayashi, Kohei KamemuraKoichi Yamamoto, Michio Otsuki, Shintaro Okamura, Shoichiro Izawa, Ryuji Okamoto, Kouichi Tamura, Akiyo Tanabe, Mitsuhide Naruse

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Left ventricular hypertrophy (LVH) is often seen in patients with primary aldosteronism (PA), and the prevalence of LVH is reportedly higher among patients with PA than patients with essential hypertension. However, the correlation between aldosterone levels and LVH is undefined, and how aldosterone affects LVH in patients with PA remains unclear. We, therefore, retrospectively assessed a large PA database established by the multicenter JPAS (Japan Primary Aldosteronism Study) to reveal the factors associated with LVH in patients with PA without suspected autonomous cortisol secretion. In the 1186 patients with PA studied, the basal plasma aldosterone concentration, plasma renin activity, and the aldosterone-to-renin ratio did not significantly correlate with left ventricular LV mass index (LVMI) in single or multiple regression analyses. However, the plasma aldosterone concentration after the captopril challenge test or saline-infusion test, which are associated with autonomous aldosterone secretion, correlated significantly with LVMI, even after adjusting for patients' backgrounds, including age and blood pressure. In addition, hypokalemia and the unilateral subtype also correlated with LVMI. Longitudinal subanalysis of medically or surgically treated patients with PA showed significant reductions in LVMI in both the surgery (63.0±18.1 to 55.3±19.5 g/m2.7, P<0.001) and drug treatment (56.8±14.1 to 52.1±13.5 g/m2.7, P<0.001) groups. Our results suggest the autonomous aldosterone secretion level, not the basal aldosterone level itself, is relevant to LVH in patients with PA. In addition, the elevated LVMI seen in patients with PA is at least partially reversible with surgical or medical treatment.

Original languageEnglish
Pages (from-to)1475-1482
Number of pages8
JournalHypertension
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Conn Syndrome
  • Mineralocorticoid Receptor Antagonists
  • aldosterone
  • cardiomegaly
  • hyperaldosteronism
  • hypertrophy
  • mineralocorticoids

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Ohno, Y., Sone, M., Inagaki, N., Kawashima, A., Takeda, Y., Yoneda, T., Kurihara, I., Itoh, H., Tsuiki, M., Ichijo, T., Katabami, T., Wada, N., Sakamoto, R., Ogawa, Y., Yoshimoto, T., Yamada, T., Kawashima, J., Matsuda, Y., Kobayashi, H., ... Naruse, M. (Accepted/In press). Nadir Aldosterone Levels after Confirmatory Tests Are Correlated with Left Ventricular Hypertrophy in Primary Aldosteronism. Hypertension, 1475-1482. https://doi.org/10.1161/HYPERTENSIONAHA.119.14601