Nakiterpiosin, a novel cytotoxic C-nor-D-homosteroid from the Okinawan sponge Terpios hoshinota

Toshiaki Teruya, Satoru Nakagawa, Tomoyuki Koyama, Kiyotake Suenaga, Masaki Kita, Daisuke Uemura

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

A novel cytotoxic compound, nakiterpiosin (1), was isolated from the Okinawan sponge Terpios hoshinota. Its structure was determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin showed potent cytotoxicity against P388 cells.

Original languageEnglish
Pages (from-to)5171-5173
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number28
DOIs
Publication statusPublished - 2003 Jul 7
Externally publishedYes

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Homosteroids
Porifera
Spectroscopic analysis
Cytotoxicity
nakiterpiosin

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Nakiterpiosin, a novel cytotoxic C-nor-D-homosteroid from the Okinawan sponge Terpios hoshinota. / Teruya, Toshiaki; Nakagawa, Satoru; Koyama, Tomoyuki; Suenaga, Kiyotake; Kita, Masaki; Uemura, Daisuke.

In: Tetrahedron Letters, Vol. 44, No. 28, 07.07.2003, p. 5171-5173.

Research output: Contribution to journalArticle

Teruya, Toshiaki ; Nakagawa, Satoru ; Koyama, Tomoyuki ; Suenaga, Kiyotake ; Kita, Masaki ; Uemura, Daisuke. / Nakiterpiosin, a novel cytotoxic C-nor-D-homosteroid from the Okinawan sponge Terpios hoshinota. In: Tetrahedron Letters. 2003 ; Vol. 44, No. 28. pp. 5171-5173.
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