Nakiterpiosin, a novel cytotoxic C-nor-D-homosteroid from the Okinawan sponge Terpios hoshinota

Toshiaki Teruya, Satoru Nakagawa, Tomoyuki Koyama, Kiyotake Suenaga, Masaki Kita, Daisuke Uemura

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A novel cytotoxic compound, nakiterpiosin (1), was isolated from the Okinawan sponge Terpios hoshinota. Its structure was determined by spectroscopic analysis. The absolute stereostructure of 1 was also determined by a modified Mosher's method. Nakiterpiosin showed potent cytotoxicity against P388 cells.

Original languageEnglish
Pages (from-to)5171-5173
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number28
DOIs
Publication statusPublished - 2003 Jul 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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