Nanohybrid carbon film for electrochemical detection of SNPs without hybridization or labeling

Dai Kato, Naoyuki Sekioka, Akio Ueda, Ryoji Kurita, Shigeru Hirono, Koji Suzuki, Osamu Niwa

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

(Figure Presented) Base discrimination: A nanocarbon film electrode exhibits sufficiently high activity to obtain sharp, quantitative peaks for all the bases in an oligonucleotide. This property allows the label-free electrochemical analysis of single-nucleotide polymorphisms (SNPs) through the discrimination of single-base differences solely by using electrochemical oxidation (see picture; ssDNA=single-strand DNA).

Original languageEnglish
Pages (from-to)6681-6684
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number35
DOIs
Publication statusPublished - 2008 Aug 18

Fingerprint

Electrochemical oxidation
Oligonucleotides
Carbon films
Nucleotides
Polymorphism
Labeling
Single Nucleotide Polymorphism
Labels
Electrodes
DNA
Carbon

Keywords

  • Carbon electrodes
  • Electrochemistry
  • Oligonucleotides
  • Oxidation
  • Polymorphism

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Nanohybrid carbon film for electrochemical detection of SNPs without hybridization or labeling. / Kato, Dai; Sekioka, Naoyuki; Ueda, Akio; Kurita, Ryoji; Hirono, Shigeru; Suzuki, Koji; Niwa, Osamu.

In: Angewandte Chemie - International Edition, Vol. 47, No. 35, 18.08.2008, p. 6681-6684.

Research output: Contribution to journalArticle

Kato, D, Sekioka, N, Ueda, A, Kurita, R, Hirono, S, Suzuki, K & Niwa, O 2008, 'Nanohybrid carbon film for electrochemical detection of SNPs without hybridization or labeling', Angewandte Chemie - International Edition, vol. 47, no. 35, pp. 6681-6684. https://doi.org/10.1002/anie.200801304
Kato, Dai ; Sekioka, Naoyuki ; Ueda, Akio ; Kurita, Ryoji ; Hirono, Shigeru ; Suzuki, Koji ; Niwa, Osamu. / Nanohybrid carbon film for electrochemical detection of SNPs without hybridization or labeling. In: Angewandte Chemie - International Edition. 2008 ; Vol. 47, No. 35. pp. 6681-6684.
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