Nanohybrid carbon film for electrochemical detection of SNPs without hybridization or labeling

Dai Kato, Naoyuki Sekioka, Akio Ueda, Ryoji Kurita, Shigeru Hirono, Koji Suzuki, Osamu Niwa

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

(Figure Presented) Base discrimination: A nanocarbon film electrode exhibits sufficiently high activity to obtain sharp, quantitative peaks for all the bases in an oligonucleotide. This property allows the label-free electrochemical analysis of single-nucleotide polymorphisms (SNPs) through the discrimination of single-base differences solely by using electrochemical oxidation (see picture; ssDNA=single-strand DNA).

Original languageEnglish
Pages (from-to)6681-6684
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number35
DOIs
Publication statusPublished - 2008 Aug 18

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Keywords

  • Carbon electrodes
  • Electrochemistry
  • Oligonucleotides
  • Oxidation
  • Polymorphism

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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