Nanohybrid carbon film for electrochemical detection of SNPs without hybridization or labeling

Dai Kato; Naoyuki Sekioka; Akio Ueda; Ryoji Kurita; Shigeru Hirono; Koji Suzuki; Osamu Niwa

doi:10.1002/anie.200801304

Nanohybrid carbon film for electrochemical detection of SNPs without hybridization or labeling

Dai Kato, Naoyuki Sekioka, Akio Ueda, Ryoji Kurita, Shigeru Hirono, Koji Suzuki, Osamu Niwa

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

(Figure Presented) Base discrimination: A nanocarbon film electrode exhibits sufficiently high activity to obtain sharp, quantitative peaks for all the bases in an oligonucleotide. This property allows the label-free electrochemical analysis of single-nucleotide polymorphisms (SNPs) through the discrimination of single-base differences solely by using electrochemical oxidation (see picture; ssDNA=single-strand DNA).

Original language	English
Pages (from-to)	6681-6684
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	35
DOIs	https://doi.org/10.1002/anie.200801304
Publication status	Published - 2008 Aug 18

Keywords

Carbon electrodes
Electrochemistry
Oligonucleotides
Oxidation
Polymorphism

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200801304

Cite this

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abstract = "(Figure Presented) Base discrimination: A nanocarbon film electrode exhibits sufficiently high activity to obtain sharp, quantitative peaks for all the bases in an oligonucleotide. This property allows the label-free electrochemical analysis of single-nucleotide polymorphisms (SNPs) through the discrimination of single-base differences solely by using electrochemical oxidation (see picture; ssDNA=single-strand DNA).",

keywords = "Carbon electrodes, Electrochemistry, Oligonucleotides, Oxidation, Polymorphism",

author = "Dai Kato and Naoyuki Sekioka and Akio Ueda and Ryoji Kurita and Shigeru Hirono and Koji Suzuki and Osamu Niwa",

year = "2008",

month = aug,

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doi = "10.1002/anie.200801304",

language = "English",

volume = "47",

pages = "6681--6684",

journal = "Angewandte Chemie - International Edition",

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T1 - Nanohybrid carbon film for electrochemical detection of SNPs without hybridization or labeling

AU - Kato, Dai

AU - Sekioka, Naoyuki

AU - Ueda, Akio

AU - Kurita, Ryoji

AU - Hirono, Shigeru

AU - Suzuki, Koji

AU - Niwa, Osamu

PY - 2008/8/18

Y1 - 2008/8/18

N2 - (Figure Presented) Base discrimination: A nanocarbon film electrode exhibits sufficiently high activity to obtain sharp, quantitative peaks for all the bases in an oligonucleotide. This property allows the label-free electrochemical analysis of single-nucleotide polymorphisms (SNPs) through the discrimination of single-base differences solely by using electrochemical oxidation (see picture; ssDNA=single-strand DNA).

AB - (Figure Presented) Base discrimination: A nanocarbon film electrode exhibits sufficiently high activity to obtain sharp, quantitative peaks for all the bases in an oligonucleotide. This property allows the label-free electrochemical analysis of single-nucleotide polymorphisms (SNPs) through the discrimination of single-base differences solely by using electrochemical oxidation (see picture; ssDNA=single-strand DNA).

KW - Carbon electrodes

KW - Electrochemistry

KW - Oligonucleotides

KW - Oxidation

KW - Polymorphism

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DO - 10.1002/anie.200801304

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VL - 47

SP - 6681

EP - 6684

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 35

ER -

Nanohybrid carbon film for electrochemical detection of SNPs without hybridization or labeling

Abstract

Keywords

ASJC Scopus subject areas

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