Nanostructured biomaterials assembled from PEGylated poly-L-lysine

Emi Kakizawa, Keiji Fujimoto

Research output: Contribution to conferencePaper

Abstract

Nature has many examples of the bottom-up fabrication to produce various functional materials. This method is expected to be utilized to create intelligent and stimuli-responsive materials in medical, food, and cosmetic fields. The secondary structure of poly-L-lysine (PLL) changed responding to pHs and temperatures among random, α helix, and β sheet forms. Poly(ethylene glycol) (PEG) was coupled with the backbone of PLL (mPEG-PLL graft polymers). PEG-rich graft polymers formed nanoparticles spontaneously by the formation of β-sheet structures when both pHs and temperatures were raised. We founded that nanoparticles crosslinked with a cleavable reagent that contains a disulfide bond collapsed and released drugs in response to reductive environment in cytoplasm. On the other hand, PEG-poor graft polymers at higher concentrations exhibited heat-induced gelation. They could disassociate again by lowering pHs or temperatures. Such biomimetic fabrication method enabled us to create nanostructured materials with huge expectations of diverse applications.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Oct 19
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

Keywords

  • Beta-sheet
  • Graft polymer
  • Poly(ethylene glycol) (PEG)
  • Poly-L-lysine(PLL)

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Kakizawa, E., & Fujimoto, K. (2006). Nanostructured biomaterials assembled from PEGylated poly-L-lysine. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.