National survey of de novo malignancy after solid organ transplantation in Japan

Takuro Miyazaki, Shuntaro Sato, Takashi Kondo, Mamoru Kusaka, Mitsukazu Gotoh, Yoshikatsu Saiki, Minoru Ono, Norihiro Kokudo, Shin Enosawa, Shigeru Satoh, Etsuko Soeda, Hiroyuki Furukawa, Eiji Kobayashi, Takeshi Nagayasu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: In Japan, there have been no national surveys on the incidence of de novo malignancy after solid organ transplantation, which is one of the leading causes of death in transplant recipients. Methods: A questionnaire was distributed to institutions that perform solid organ transplantation in Japan, and clinical information was collected from patients who underwent transplantation between 2001 and 2010 and who exhibited de novo malignancies. Results: Nine thousand two hundred ten solid organ transplants (kidney, 49.9%; liver, 45.9%; heart, 0.9%; lung, 1.2%; pancreas, 1.9%; small intestine, 0.2%) were performed. Four hundred seventy-nine (5.2%) cases of de novo malignancy were identified. The transplanted organs of the patients included the kidney (n = 479, 54.8%), liver (n = 186, 38.8%), heart (n = 5, 0.1%), lung (n = 18, 3.8%), pancreas (n = 9, 1.9%), and small intestine (n = 1, 0.02%). The most common malignancies were post-transplant lymphoproliferative disorder (n = 87) and cancers of the kidney (n = 43), stomach (n = 41), large intestine (n = 41), and lung (n = 36). Conclusions: This is the first national survey of the incidence of de novo malignancy in Japan. Further study is required to identify the risk of de novo malignancy in organ transplant recipients in comparison to the general population, namely the standardized incidence ratio.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalSurgery Today
DOIs
Publication statusAccepted/In press - 2018 Jan 29

Fingerprint

Organ Transplantation
Japan
Neoplasms
Transplants
Lung
Small Intestine
Pancreas
Incidence
Kidney
Lymphoproliferative Disorders
Kidney Neoplasms
Liver
Large Intestine
Surveys and Questionnaires
Cause of Death
Stomach
Transplantation
Population

Keywords

  • Cancer screening
  • De novo malignancy
  • Immunosuppression
  • Post-transplant lymphoproliferative disorder
  • Solid organ transplantation

ASJC Scopus subject areas

  • Surgery

Cite this

Miyazaki, T., Sato, S., Kondo, T., Kusaka, M., Gotoh, M., Saiki, Y., ... Nagayasu, T. (Accepted/In press). National survey of de novo malignancy after solid organ transplantation in Japan. Surgery Today, 1-7. https://doi.org/10.1007/s00595-018-1628-9

National survey of de novo malignancy after solid organ transplantation in Japan. / Miyazaki, Takuro; Sato, Shuntaro; Kondo, Takashi; Kusaka, Mamoru; Gotoh, Mitsukazu; Saiki, Yoshikatsu; Ono, Minoru; Kokudo, Norihiro; Enosawa, Shin; Satoh, Shigeru; Soeda, Etsuko; Furukawa, Hiroyuki; Kobayashi, Eiji; Nagayasu, Takeshi.

In: Surgery Today, 29.01.2018, p. 1-7.

Research output: Contribution to journalArticle

Miyazaki, T, Sato, S, Kondo, T, Kusaka, M, Gotoh, M, Saiki, Y, Ono, M, Kokudo, N, Enosawa, S, Satoh, S, Soeda, E, Furukawa, H, Kobayashi, E & Nagayasu, T 2018, 'National survey of de novo malignancy after solid organ transplantation in Japan', Surgery Today, pp. 1-7. https://doi.org/10.1007/s00595-018-1628-9
Miyazaki, Takuro ; Sato, Shuntaro ; Kondo, Takashi ; Kusaka, Mamoru ; Gotoh, Mitsukazu ; Saiki, Yoshikatsu ; Ono, Minoru ; Kokudo, Norihiro ; Enosawa, Shin ; Satoh, Shigeru ; Soeda, Etsuko ; Furukawa, Hiroyuki ; Kobayashi, Eiji ; Nagayasu, Takeshi. / National survey of de novo malignancy after solid organ transplantation in Japan. In: Surgery Today. 2018 ; pp. 1-7.
@article{07156cae67aa4525ba0d7134826e70c8,
title = "National survey of de novo malignancy after solid organ transplantation in Japan",
abstract = "Purpose: In Japan, there have been no national surveys on the incidence of de novo malignancy after solid organ transplantation, which is one of the leading causes of death in transplant recipients. Methods: A questionnaire was distributed to institutions that perform solid organ transplantation in Japan, and clinical information was collected from patients who underwent transplantation between 2001 and 2010 and who exhibited de novo malignancies. Results: Nine thousand two hundred ten solid organ transplants (kidney, 49.9{\%}; liver, 45.9{\%}; heart, 0.9{\%}; lung, 1.2{\%}; pancreas, 1.9{\%}; small intestine, 0.2{\%}) were performed. Four hundred seventy-nine (5.2{\%}) cases of de novo malignancy were identified. The transplanted organs of the patients included the kidney (n = 479, 54.8{\%}), liver (n = 186, 38.8{\%}), heart (n = 5, 0.1{\%}), lung (n = 18, 3.8{\%}), pancreas (n = 9, 1.9{\%}), and small intestine (n = 1, 0.02{\%}). The most common malignancies were post-transplant lymphoproliferative disorder (n = 87) and cancers of the kidney (n = 43), stomach (n = 41), large intestine (n = 41), and lung (n = 36). Conclusions: This is the first national survey of the incidence of de novo malignancy in Japan. Further study is required to identify the risk of de novo malignancy in organ transplant recipients in comparison to the general population, namely the standardized incidence ratio.",
keywords = "Cancer screening, De novo malignancy, Immunosuppression, Post-transplant lymphoproliferative disorder, Solid organ transplantation",
author = "Takuro Miyazaki and Shuntaro Sato and Takashi Kondo and Mamoru Kusaka and Mitsukazu Gotoh and Yoshikatsu Saiki and Minoru Ono and Norihiro Kokudo and Shin Enosawa and Shigeru Satoh and Etsuko Soeda and Hiroyuki Furukawa and Eiji Kobayashi and Takeshi Nagayasu",
year = "2018",
month = "1",
day = "29",
doi = "10.1007/s00595-018-1628-9",
language = "English",
pages = "1--7",
journal = "Surgery Today",
issn = "0941-1291",
publisher = "Springer Japan",

}

TY - JOUR

T1 - National survey of de novo malignancy after solid organ transplantation in Japan

AU - Miyazaki, Takuro

AU - Sato, Shuntaro

AU - Kondo, Takashi

AU - Kusaka, Mamoru

AU - Gotoh, Mitsukazu

AU - Saiki, Yoshikatsu

AU - Ono, Minoru

AU - Kokudo, Norihiro

AU - Enosawa, Shin

AU - Satoh, Shigeru

AU - Soeda, Etsuko

AU - Furukawa, Hiroyuki

AU - Kobayashi, Eiji

AU - Nagayasu, Takeshi

PY - 2018/1/29

Y1 - 2018/1/29

N2 - Purpose: In Japan, there have been no national surveys on the incidence of de novo malignancy after solid organ transplantation, which is one of the leading causes of death in transplant recipients. Methods: A questionnaire was distributed to institutions that perform solid organ transplantation in Japan, and clinical information was collected from patients who underwent transplantation between 2001 and 2010 and who exhibited de novo malignancies. Results: Nine thousand two hundred ten solid organ transplants (kidney, 49.9%; liver, 45.9%; heart, 0.9%; lung, 1.2%; pancreas, 1.9%; small intestine, 0.2%) were performed. Four hundred seventy-nine (5.2%) cases of de novo malignancy were identified. The transplanted organs of the patients included the kidney (n = 479, 54.8%), liver (n = 186, 38.8%), heart (n = 5, 0.1%), lung (n = 18, 3.8%), pancreas (n = 9, 1.9%), and small intestine (n = 1, 0.02%). The most common malignancies were post-transplant lymphoproliferative disorder (n = 87) and cancers of the kidney (n = 43), stomach (n = 41), large intestine (n = 41), and lung (n = 36). Conclusions: This is the first national survey of the incidence of de novo malignancy in Japan. Further study is required to identify the risk of de novo malignancy in organ transplant recipients in comparison to the general population, namely the standardized incidence ratio.

AB - Purpose: In Japan, there have been no national surveys on the incidence of de novo malignancy after solid organ transplantation, which is one of the leading causes of death in transplant recipients. Methods: A questionnaire was distributed to institutions that perform solid organ transplantation in Japan, and clinical information was collected from patients who underwent transplantation between 2001 and 2010 and who exhibited de novo malignancies. Results: Nine thousand two hundred ten solid organ transplants (kidney, 49.9%; liver, 45.9%; heart, 0.9%; lung, 1.2%; pancreas, 1.9%; small intestine, 0.2%) were performed. Four hundred seventy-nine (5.2%) cases of de novo malignancy were identified. The transplanted organs of the patients included the kidney (n = 479, 54.8%), liver (n = 186, 38.8%), heart (n = 5, 0.1%), lung (n = 18, 3.8%), pancreas (n = 9, 1.9%), and small intestine (n = 1, 0.02%). The most common malignancies were post-transplant lymphoproliferative disorder (n = 87) and cancers of the kidney (n = 43), stomach (n = 41), large intestine (n = 41), and lung (n = 36). Conclusions: This is the first national survey of the incidence of de novo malignancy in Japan. Further study is required to identify the risk of de novo malignancy in organ transplant recipients in comparison to the general population, namely the standardized incidence ratio.

KW - Cancer screening

KW - De novo malignancy

KW - Immunosuppression

KW - Post-transplant lymphoproliferative disorder

KW - Solid organ transplantation

UR - http://www.scopus.com/inward/record.url?scp=85041102096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85041102096&partnerID=8YFLogxK

U2 - 10.1007/s00595-018-1628-9

DO - 10.1007/s00595-018-1628-9

M3 - Article

SP - 1

EP - 7

JO - Surgery Today

JF - Surgery Today

SN - 0941-1291

ER -