Nationwide investigation of the current status of therapeutic neuroendoscopy for ventricular and paraventricular tumors in Japan

Clinical article

Nakamasa Hayashi, Hisayuki Murai, Shoichiro Ishihara, Takayuki Kitamura, Tamotsu Miki, Tomoru Miwa, Masakazu Miyajima, Kenichi Nishiyama, Takayuki Oohira, Shigeki Ono, Tomonari Suzuki, Shingo Takano, Isao Date, Naokatsu Saeki, Shunro End

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Object. The authors report their investigation on the current status of neuroendoscopic biopsy for ventricular and paraventricular tumors as well as treatment for associated hydrocephalus in Japan. Methods. Patients who had undergone therapeutic neuroendoscopy between 2005 and 2009 were included in this study. The main items examined were age; sex; localization of tumor; pathological diagnosis using biopsy; the presence, treatment, and efficacy of treatment of associated hydrocephalus; perioperative complications; activities of daily living (ADL) before and after therapeutic neuroendoscopy; and the presence of dissemination during the postoperative course. Results. Seven hundred fourteen patients from 123 sites (462 male and 252 female patients, mean age 33.3 years) were enrolled. Localization of the tumor was mainly classified into the lateral ventricle in 91 patients, the third ventricle in 339, the fourth ventricle in 18, the suprasellar region in 75, and other paraventricular areas in 191 patients. The most commonly observed tumors were germ cell tumors in the third ventricle (177 cases [39%]), cystic lesions in the suprasellar region (56 cases [75%]), and astrocytic tumors in the thalamus-basal ganglia (71 cases [38%]). Although 641 (92.8%) of 691 patients could receive neuroendoscopic diagnosis using biopsy, the diagnosis obtained with endoscopic biopsy differed from the final diagnosis based on subsequent craniotomy in 18 patients and clinical course in 3 patients. Of these 21 patients, 7 had astrocytic tumors, 4 had pineal tumors, 6 had germ cell tumors, and 4 had other tumors. The final diagnostic accuracy rate was 89.7%. Associated hydrocephalus was observed in 517 patients (72.4%), of whom 316 and 39 underwent third ventriculostomy and fenestration of the septum, respectively. The response rates were 96.2% and 89.7%, respectively. Third ventriculostomy was required for recurrence of hydrocephalus in 41 patients (13.0%), and the long-term response rate was therefore 83.2% (263 of 316 patients). Perioperative complications other than fever, such as new onset of or progressive hydrocephalus, infection due to CSF leakage, and bleeding in the ventricle or tumor, were found in 81 patients (11.3%). The median Karnofsky Performance Scale score before endoscopic surgery was 80, but it increased to 90 after surgery. The score was thus significantly increased after surgery (p &λτ; 0.0001, Mann-Whitney U-test). Activities of daily living after surgery decreased due to perioperative complications in 15 patients (2.1%). The incidence of new dissemination after endoscopic biopsy was 6.8% and not high compared with routine surgical treatment. Conclusions. The authors concluded that neuroendoscopic diagnosis using biopsy for ventricular and paraventricular tumors is adequately accurate and safe. It was demonstrated that endoscopic procedures play important roles not only in the treatment of hydrocephalus associated with intra- and paraventricular tumors but also in significantly improving ADL. Furthermore, the long-term outcome of endoscopic third ventriculostomy was clearly favorable.

Original languageEnglish
Pages (from-to)1147-1157
Number of pages11
JournalJournal of Neurosurgery
Volume115
Issue number6
DOIs
Publication statusPublished - 2011 Dec

Fingerprint

Neuroendoscopy
Japan
Hydrocephalus
Neoplasms
Ventriculostomy
Biopsy
Therapeutics
Activities of Daily Living
Third Ventricle
Germ Cell and Embryonal Neoplasms
Pinealoma
Karnofsky Performance Status
Fourth Ventricle
Craniotomy
Lateral Ventricles

Keywords

  • Brain tumor
  • Endoscopic biopsy
  • Hydrocephalus
  • Septostomy
  • Third ventriculostomy
  • Vascular disorders

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Nationwide investigation of the current status of therapeutic neuroendoscopy for ventricular and paraventricular tumors in Japan : Clinical article. / Hayashi, Nakamasa; Murai, Hisayuki; Ishihara, Shoichiro; Kitamura, Takayuki; Miki, Tamotsu; Miwa, Tomoru; Miyajima, Masakazu; Nishiyama, Kenichi; Oohira, Takayuki; Ono, Shigeki; Suzuki, Tomonari; Takano, Shingo; Date, Isao; Saeki, Naokatsu; End, Shunro.

In: Journal of Neurosurgery, Vol. 115, No. 6, 12.2011, p. 1147-1157.

Research output: Contribution to journalArticle

Hayashi, N, Murai, H, Ishihara, S, Kitamura, T, Miki, T, Miwa, T, Miyajima, M, Nishiyama, K, Oohira, T, Ono, S, Suzuki, T, Takano, S, Date, I, Saeki, N & End, S 2011, 'Nationwide investigation of the current status of therapeutic neuroendoscopy for ventricular and paraventricular tumors in Japan: Clinical article', Journal of Neurosurgery, vol. 115, no. 6, pp. 1147-1157. https://doi.org/10.3171/2011.7.JNS101976
Hayashi, Nakamasa ; Murai, Hisayuki ; Ishihara, Shoichiro ; Kitamura, Takayuki ; Miki, Tamotsu ; Miwa, Tomoru ; Miyajima, Masakazu ; Nishiyama, Kenichi ; Oohira, Takayuki ; Ono, Shigeki ; Suzuki, Tomonari ; Takano, Shingo ; Date, Isao ; Saeki, Naokatsu ; End, Shunro. / Nationwide investigation of the current status of therapeutic neuroendoscopy for ventricular and paraventricular tumors in Japan : Clinical article. In: Journal of Neurosurgery. 2011 ; Vol. 115, No. 6. pp. 1147-1157.
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abstract = "Object. The authors report their investigation on the current status of neuroendoscopic biopsy for ventricular and paraventricular tumors as well as treatment for associated hydrocephalus in Japan. Methods. Patients who had undergone therapeutic neuroendoscopy between 2005 and 2009 were included in this study. The main items examined were age; sex; localization of tumor; pathological diagnosis using biopsy; the presence, treatment, and efficacy of treatment of associated hydrocephalus; perioperative complications; activities of daily living (ADL) before and after therapeutic neuroendoscopy; and the presence of dissemination during the postoperative course. Results. Seven hundred fourteen patients from 123 sites (462 male and 252 female patients, mean age 33.3 years) were enrolled. Localization of the tumor was mainly classified into the lateral ventricle in 91 patients, the third ventricle in 339, the fourth ventricle in 18, the suprasellar region in 75, and other paraventricular areas in 191 patients. The most commonly observed tumors were germ cell tumors in the third ventricle (177 cases [39{\%}]), cystic lesions in the suprasellar region (56 cases [75{\%}]), and astrocytic tumors in the thalamus-basal ganglia (71 cases [38{\%}]). Although 641 (92.8{\%}) of 691 patients could receive neuroendoscopic diagnosis using biopsy, the diagnosis obtained with endoscopic biopsy differed from the final diagnosis based on subsequent craniotomy in 18 patients and clinical course in 3 patients. Of these 21 patients, 7 had astrocytic tumors, 4 had pineal tumors, 6 had germ cell tumors, and 4 had other tumors. The final diagnostic accuracy rate was 89.7{\%}. Associated hydrocephalus was observed in 517 patients (72.4{\%}), of whom 316 and 39 underwent third ventriculostomy and fenestration of the septum, respectively. The response rates were 96.2{\%} and 89.7{\%}, respectively. Third ventriculostomy was required for recurrence of hydrocephalus in 41 patients (13.0{\%}), and the long-term response rate was therefore 83.2{\%} (263 of 316 patients). Perioperative complications other than fever, such as new onset of or progressive hydrocephalus, infection due to CSF leakage, and bleeding in the ventricle or tumor, were found in 81 patients (11.3{\%}). The median Karnofsky Performance Scale score before endoscopic surgery was 80, but it increased to 90 after surgery. The score was thus significantly increased after surgery (p &λτ; 0.0001, Mann-Whitney U-test). Activities of daily living after surgery decreased due to perioperative complications in 15 patients (2.1{\%}). The incidence of new dissemination after endoscopic biopsy was 6.8{\%} and not high compared with routine surgical treatment. Conclusions. The authors concluded that neuroendoscopic diagnosis using biopsy for ventricular and paraventricular tumors is adequately accurate and safe. It was demonstrated that endoscopic procedures play important roles not only in the treatment of hydrocephalus associated with intra- and paraventricular tumors but also in significantly improving ADL. Furthermore, the long-term outcome of endoscopic third ventriculostomy was clearly favorable.",
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TY - JOUR

T1 - Nationwide investigation of the current status of therapeutic neuroendoscopy for ventricular and paraventricular tumors in Japan

T2 - Clinical article

AU - Hayashi, Nakamasa

AU - Murai, Hisayuki

AU - Ishihara, Shoichiro

AU - Kitamura, Takayuki

AU - Miki, Tamotsu

AU - Miwa, Tomoru

AU - Miyajima, Masakazu

AU - Nishiyama, Kenichi

AU - Oohira, Takayuki

AU - Ono, Shigeki

AU - Suzuki, Tomonari

AU - Takano, Shingo

AU - Date, Isao

AU - Saeki, Naokatsu

AU - End, Shunro

PY - 2011/12

Y1 - 2011/12

N2 - Object. The authors report their investigation on the current status of neuroendoscopic biopsy for ventricular and paraventricular tumors as well as treatment for associated hydrocephalus in Japan. Methods. Patients who had undergone therapeutic neuroendoscopy between 2005 and 2009 were included in this study. The main items examined were age; sex; localization of tumor; pathological diagnosis using biopsy; the presence, treatment, and efficacy of treatment of associated hydrocephalus; perioperative complications; activities of daily living (ADL) before and after therapeutic neuroendoscopy; and the presence of dissemination during the postoperative course. Results. Seven hundred fourteen patients from 123 sites (462 male and 252 female patients, mean age 33.3 years) were enrolled. Localization of the tumor was mainly classified into the lateral ventricle in 91 patients, the third ventricle in 339, the fourth ventricle in 18, the suprasellar region in 75, and other paraventricular areas in 191 patients. The most commonly observed tumors were germ cell tumors in the third ventricle (177 cases [39%]), cystic lesions in the suprasellar region (56 cases [75%]), and astrocytic tumors in the thalamus-basal ganglia (71 cases [38%]). Although 641 (92.8%) of 691 patients could receive neuroendoscopic diagnosis using biopsy, the diagnosis obtained with endoscopic biopsy differed from the final diagnosis based on subsequent craniotomy in 18 patients and clinical course in 3 patients. Of these 21 patients, 7 had astrocytic tumors, 4 had pineal tumors, 6 had germ cell tumors, and 4 had other tumors. The final diagnostic accuracy rate was 89.7%. Associated hydrocephalus was observed in 517 patients (72.4%), of whom 316 and 39 underwent third ventriculostomy and fenestration of the septum, respectively. The response rates were 96.2% and 89.7%, respectively. Third ventriculostomy was required for recurrence of hydrocephalus in 41 patients (13.0%), and the long-term response rate was therefore 83.2% (263 of 316 patients). Perioperative complications other than fever, such as new onset of or progressive hydrocephalus, infection due to CSF leakage, and bleeding in the ventricle or tumor, were found in 81 patients (11.3%). The median Karnofsky Performance Scale score before endoscopic surgery was 80, but it increased to 90 after surgery. The score was thus significantly increased after surgery (p &λτ; 0.0001, Mann-Whitney U-test). Activities of daily living after surgery decreased due to perioperative complications in 15 patients (2.1%). The incidence of new dissemination after endoscopic biopsy was 6.8% and not high compared with routine surgical treatment. Conclusions. The authors concluded that neuroendoscopic diagnosis using biopsy for ventricular and paraventricular tumors is adequately accurate and safe. It was demonstrated that endoscopic procedures play important roles not only in the treatment of hydrocephalus associated with intra- and paraventricular tumors but also in significantly improving ADL. Furthermore, the long-term outcome of endoscopic third ventriculostomy was clearly favorable.

AB - Object. The authors report their investigation on the current status of neuroendoscopic biopsy for ventricular and paraventricular tumors as well as treatment for associated hydrocephalus in Japan. Methods. Patients who had undergone therapeutic neuroendoscopy between 2005 and 2009 were included in this study. The main items examined were age; sex; localization of tumor; pathological diagnosis using biopsy; the presence, treatment, and efficacy of treatment of associated hydrocephalus; perioperative complications; activities of daily living (ADL) before and after therapeutic neuroendoscopy; and the presence of dissemination during the postoperative course. Results. Seven hundred fourteen patients from 123 sites (462 male and 252 female patients, mean age 33.3 years) were enrolled. Localization of the tumor was mainly classified into the lateral ventricle in 91 patients, the third ventricle in 339, the fourth ventricle in 18, the suprasellar region in 75, and other paraventricular areas in 191 patients. The most commonly observed tumors were germ cell tumors in the third ventricle (177 cases [39%]), cystic lesions in the suprasellar region (56 cases [75%]), and astrocytic tumors in the thalamus-basal ganglia (71 cases [38%]). Although 641 (92.8%) of 691 patients could receive neuroendoscopic diagnosis using biopsy, the diagnosis obtained with endoscopic biopsy differed from the final diagnosis based on subsequent craniotomy in 18 patients and clinical course in 3 patients. Of these 21 patients, 7 had astrocytic tumors, 4 had pineal tumors, 6 had germ cell tumors, and 4 had other tumors. The final diagnostic accuracy rate was 89.7%. Associated hydrocephalus was observed in 517 patients (72.4%), of whom 316 and 39 underwent third ventriculostomy and fenestration of the septum, respectively. The response rates were 96.2% and 89.7%, respectively. Third ventriculostomy was required for recurrence of hydrocephalus in 41 patients (13.0%), and the long-term response rate was therefore 83.2% (263 of 316 patients). Perioperative complications other than fever, such as new onset of or progressive hydrocephalus, infection due to CSF leakage, and bleeding in the ventricle or tumor, were found in 81 patients (11.3%). The median Karnofsky Performance Scale score before endoscopic surgery was 80, but it increased to 90 after surgery. The score was thus significantly increased after surgery (p &λτ; 0.0001, Mann-Whitney U-test). Activities of daily living after surgery decreased due to perioperative complications in 15 patients (2.1%). The incidence of new dissemination after endoscopic biopsy was 6.8% and not high compared with routine surgical treatment. Conclusions. The authors concluded that neuroendoscopic diagnosis using biopsy for ventricular and paraventricular tumors is adequately accurate and safe. It was demonstrated that endoscopic procedures play important roles not only in the treatment of hydrocephalus associated with intra- and paraventricular tumors but also in significantly improving ADL. Furthermore, the long-term outcome of endoscopic third ventriculostomy was clearly favorable.

KW - Brain tumor

KW - Endoscopic biopsy

KW - Hydrocephalus

KW - Septostomy

KW - Third ventriculostomy

KW - Vascular disorders

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