Abstract
To investigate the trends of antimicrobial resistance in pathogens isolated from surgical site infections (SSI), a Japanese surveillance committee conducted the first nationwide survey. Seven main organisms were collected from SSI at 27 medical centers in 2010 and were shipped to a central laboratory for antimicrobial susceptibility testing. A total of 702 isolates from 586 patients with SSI were included. Staphylococcus aureus (20.4 %) and Enterococcus faecalis (19.5 %) were the most common isolates, followed by Pseudomonas aeruginosa (15.4 %) and Bacteroides fragilis group (15.4 %). Methicillin-resistant S. aureus among S. aureus was 72.0 %. Vancomycin MIC 2 μg/ml strains accounted for 9.7 %. In Escherichia coli, 11 of 95 strains produced extended-spectrum β-lactamase (Klebsiella pneumoniae, 0/53 strains). Of E. coli strains, 8.4 % were resistant to ceftazidime (CAZ) and 26.3 % to ciprofloxacin (CPFX). No P. aeruginosa strains produced metallo-β-lactamase. In P. aeruginosa, the resistance rates were 7.4 % to tazobactam/piperacillin (TAZ/PIPC), 10.2 % to imipenem (IPM), 2.8 % to meropenem, cefepime, and CPFX, and 0 % to gentamicin. In the B. fragilis group, the rates were 28.6 % to clindamycin, 5.7 % to cefmetazole, 2.9 % to TAZ/PIPC and IPM, and 0 % to metronidazole (Bacteroides thetaiotaomicron; 59.1, 36.4, 0, 0, 0 %). MIC90 of P. aeruginosa isolated 15 days or later after surgery rose in TAZ/PIPC, CAZ, IPM, and CPFX. In patients with American Society of Anesthesiologists (ASA) score ≥3, the resistance rates of P. aeruginosa to TAZ/PIPC and CAZ were higher than in patients with ASA ≤2. The data obtained in this study revealed the trend of the spread of resistance among common species that cause SSI. Timing of isolation from surgery and the patient's physical status affected the selection of resistant organisms.
| Original language | English |
|---|---|
| Pages (from-to) | 816-826 |
| Number of pages | 11 |
| Journal | Journal of Infection and Chemotherapy |
| Volume | 18 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2012 Dec |
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Keywords
- Antibiotic susceptibility
- Bacteroides fragilis group
- Surgical site infections
- Surveillance
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases
- Medicine(all)
Cite this
Nationwide surveillance of antimicrobial susceptibility patterns of pathogens isolated from surgical site infections (SSI) in Japan. / Takesue, Yoshio; Watanabe, Akira; Hanaki, Hideaki; Kusachi, Shinya; Matsumoto, Tetsuro; Iwamoto, Aikichi; Totsuka, Kyoichi; Sunakawa, Keisuke; Yagisawa, Morimasa; Sato, Junko; Oguri, Toyoko; Nakanishi, Kunio; Sumiyama, Yoshinobu; Kitagawa, Yuukou; Wakabayashi, Go; Koyama, Isamu; Yanaga, Katsuhiko; Konishi, Toshiro; Fukushima, Ryoji; Seki, Shiko; Imai, Shun; Shintani, Tsunehiro; Tsukada, Hiroki; Tsukada, Kazuhiro; Omura, Kenji; Mikamo, Hiroshige; Takeyama, Hiromitsu; Kusunoki, Masato; Kubo, Shoji; Shimizu, Junzo; Hirai, Toshihiro; Ohge, Hiroki; Kadowaki, Akio; Okamoto, Kohji; Yanagihara, Katsunori.
In: Journal of Infection and Chemotherapy, Vol. 18, No. 6, 12.2012, p. 816-826.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nationwide surveillance of antimicrobial susceptibility patterns of pathogens isolated from surgical site infections (SSI) in Japan
AU - Takesue, Yoshio
AU - Watanabe, Akira
AU - Hanaki, Hideaki
AU - Kusachi, Shinya
AU - Matsumoto, Tetsuro
AU - Iwamoto, Aikichi
AU - Totsuka, Kyoichi
AU - Sunakawa, Keisuke
AU - Yagisawa, Morimasa
AU - Sato, Junko
AU - Oguri, Toyoko
AU - Nakanishi, Kunio
AU - Sumiyama, Yoshinobu
AU - Kitagawa, Yuukou
AU - Wakabayashi, Go
AU - Koyama, Isamu
AU - Yanaga, Katsuhiko
AU - Konishi, Toshiro
AU - Fukushima, Ryoji
AU - Seki, Shiko
AU - Imai, Shun
AU - Shintani, Tsunehiro
AU - Tsukada, Hiroki
AU - Tsukada, Kazuhiro
AU - Omura, Kenji
AU - Mikamo, Hiroshige
AU - Takeyama, Hiromitsu
AU - Kusunoki, Masato
AU - Kubo, Shoji
AU - Shimizu, Junzo
AU - Hirai, Toshihiro
AU - Ohge, Hiroki
AU - Kadowaki, Akio
AU - Okamoto, Kohji
AU - Yanagihara, Katsunori
PY - 2012/12
Y1 - 2012/12
N2 - To investigate the trends of antimicrobial resistance in pathogens isolated from surgical site infections (SSI), a Japanese surveillance committee conducted the first nationwide survey. Seven main organisms were collected from SSI at 27 medical centers in 2010 and were shipped to a central laboratory for antimicrobial susceptibility testing. A total of 702 isolates from 586 patients with SSI were included. Staphylococcus aureus (20.4 %) and Enterococcus faecalis (19.5 %) were the most common isolates, followed by Pseudomonas aeruginosa (15.4 %) and Bacteroides fragilis group (15.4 %). Methicillin-resistant S. aureus among S. aureus was 72.0 %. Vancomycin MIC 2 μg/ml strains accounted for 9.7 %. In Escherichia coli, 11 of 95 strains produced extended-spectrum β-lactamase (Klebsiella pneumoniae, 0/53 strains). Of E. coli strains, 8.4 % were resistant to ceftazidime (CAZ) and 26.3 % to ciprofloxacin (CPFX). No P. aeruginosa strains produced metallo-β-lactamase. In P. aeruginosa, the resistance rates were 7.4 % to tazobactam/piperacillin (TAZ/PIPC), 10.2 % to imipenem (IPM), 2.8 % to meropenem, cefepime, and CPFX, and 0 % to gentamicin. In the B. fragilis group, the rates were 28.6 % to clindamycin, 5.7 % to cefmetazole, 2.9 % to TAZ/PIPC and IPM, and 0 % to metronidazole (Bacteroides thetaiotaomicron; 59.1, 36.4, 0, 0, 0 %). MIC90 of P. aeruginosa isolated 15 days or later after surgery rose in TAZ/PIPC, CAZ, IPM, and CPFX. In patients with American Society of Anesthesiologists (ASA) score ≥3, the resistance rates of P. aeruginosa to TAZ/PIPC and CAZ were higher than in patients with ASA ≤2. The data obtained in this study revealed the trend of the spread of resistance among common species that cause SSI. Timing of isolation from surgery and the patient's physical status affected the selection of resistant organisms.
AB - To investigate the trends of antimicrobial resistance in pathogens isolated from surgical site infections (SSI), a Japanese surveillance committee conducted the first nationwide survey. Seven main organisms were collected from SSI at 27 medical centers in 2010 and were shipped to a central laboratory for antimicrobial susceptibility testing. A total of 702 isolates from 586 patients with SSI were included. Staphylococcus aureus (20.4 %) and Enterococcus faecalis (19.5 %) were the most common isolates, followed by Pseudomonas aeruginosa (15.4 %) and Bacteroides fragilis group (15.4 %). Methicillin-resistant S. aureus among S. aureus was 72.0 %. Vancomycin MIC 2 μg/ml strains accounted for 9.7 %. In Escherichia coli, 11 of 95 strains produced extended-spectrum β-lactamase (Klebsiella pneumoniae, 0/53 strains). Of E. coli strains, 8.4 % were resistant to ceftazidime (CAZ) and 26.3 % to ciprofloxacin (CPFX). No P. aeruginosa strains produced metallo-β-lactamase. In P. aeruginosa, the resistance rates were 7.4 % to tazobactam/piperacillin (TAZ/PIPC), 10.2 % to imipenem (IPM), 2.8 % to meropenem, cefepime, and CPFX, and 0 % to gentamicin. In the B. fragilis group, the rates were 28.6 % to clindamycin, 5.7 % to cefmetazole, 2.9 % to TAZ/PIPC and IPM, and 0 % to metronidazole (Bacteroides thetaiotaomicron; 59.1, 36.4, 0, 0, 0 %). MIC90 of P. aeruginosa isolated 15 days or later after surgery rose in TAZ/PIPC, CAZ, IPM, and CPFX. In patients with American Society of Anesthesiologists (ASA) score ≥3, the resistance rates of P. aeruginosa to TAZ/PIPC and CAZ were higher than in patients with ASA ≤2. The data obtained in this study revealed the trend of the spread of resistance among common species that cause SSI. Timing of isolation from surgery and the patient's physical status affected the selection of resistant organisms.
KW - Antibiotic susceptibility
KW - Bacteroides fragilis group
KW - Surgical site infections
KW - Surveillance
UR - http://www.scopus.com/inward/record.url?scp=84880443113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880443113&partnerID=8YFLogxK
U2 - 10.1007/s10156-012-0509-1
DO - 10.1007/s10156-012-0509-1
M3 - Article
C2 - 23143280
AN - SCOPUS:84880443113
VL - 18
SP - 816
EP - 826
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
SN - 1341-321X
IS - 6
ER -