Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2010: General view of the pathogens' antibacterial susceptibility

Katsunori Yanagihara, Junichi Kadota, Nobuki Aoki, Tetsuya Matsumoto, Masaki Yoshida, Morimasa Yagisawa, Toyoko Oguri, Junko Sato, Kazuhiko Ogasawara, Tomotaro Wakamura, Keisuke Sunakawa, Akira Watanabe, Satoshi Iwata, Mitsuo Kaku, Hideaki Hanaki, Yoshinobu Ohsaki, Tomohisa Watari, Eri Toyoshima, Kenichi Takeuchi, Mayumi ShiokoshiHiroaki Takeda, Makoto Miki, Toshio Kumagai, Susumu Nakanowatari, Hiroshi Takahashi, Mutsuko Utagawa, Hajime Nishiya, Sayoko Kawakami, Nobuyuki Kobayashi, Jin Takasaki, Kazuhisa Mezaki, Hisami Konosaki, Yasuko Aoki, Yumiko Yamamoto, Michi Shoji, Hajime Goto, Takeshi Saraya, Daisuke Kurai, Mitsuhiro Okazaki, Yoshihito Niki, Koichiro Yoshida, Akihiko Kawana, Katsu Saionji, Yuji Fujikura, Naoki Miyazawa, Makoto Kudo, Yoshimi Sato, Masaki Yamamoto, Takashi Yoshida, Masahiko Nakamura, Hiroki Tsukada, Yumiko Imai, Ayami Tsukada, Satoshi Kawasaki, Yasuo Honma, Toshinobu Yamamoto, Nobuyoshi Ban, Hiroshige Mikamo, Haruki Sawamura, Takayuki Miyara, Hirofumi Toda, Kaori Sato, Tadahiro Nakamura, Yasunori Fujikawa, Noriko Mitsuno, Keiichi Mikasa, Kei Kasahara, Reiko Sano, Keisuke Sugimoto, Seishi Asari, Isao Nishi, Masahiro Toyokawa, Naoyuki Miyashita, Yutaka Koguchi, Nobuchika Kusano, Eiichirou Mihara, Masao Kuwabara, Yaeko Watanabe, Yuji Kawasaki, Kenichi Takeda, Hirokazu Tokuyasu, Kayoko Masui, Kiyoshi Negayama, Kazufumi Hiramatsu, Yosuke Aoki, Mami Fukuoka, Hiroki Magarifuchi, Zenzo Nagasawa, Moritaka Suga, Hiroyuki Muranaka, Yoshitomo Morinaga, Junichi Honda, Masaki Fujita

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from patients in Japan, was conducted by Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases and Japanese Society for Clinical Microbiology in 2010.The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period from January and April 2010 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical and Laboratory Standard Institutes using maximum 45 antibacterial agents.Susceptibility testing was evaluable with 954 strains (206 Staphylococcus aureus, 189 Streptococcus pneumoniae, 4 Streptococcus pyogenes, 182 Haemophilus influenzae, 74 Moraxella catarrhalis, 139 Klebsiella pneumoniae and 160 Pseudomonas aeruginosa). Ratio of methicillin-resistant S.aureus was as high as 50.5%, and those of penicillin-intermediate and -resistant S.pneumoniae were 1.1% and 0.0%, respectively. Among H.influenzae, 17.6% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately resistant, 33.5% to be β-lactamase-non-producing ABPC-resistant and 11.0% to be β-lactamase-producing ABPC-resistant strains. Extended spectrum β-lactamase-producing K.pneumoniae and multi-drug resistant P.aeruginosa with metallo β-lactamase were 2.9% and 0.6%, respectively.Continuous national surveillance of antimicrobial susceptibility of respiratory pathogens is crucial in order to monitor changing patterns of susceptibility and to be able to update treatment recommendations on a regular basis.

Original languageEnglish
Pages (from-to)410-420
Number of pages11
JournalJournal of Infection and Chemotherapy
Volume21
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

Keywords

  • Resistance
  • Respiratory tract infection
  • Surveillance
  • Susceptibility

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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