Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan

Satoshi Takahashi, Ryoichi Hamasuna, Mitsuru Yasuda, Kiyohito Ishikawa, Hiroshi Hayami, Shinya Uehara, Shingo Yamamoto, Shinichi Minamitani, Junichi Kadota, Satoshi Iwata, Mitsuo Kaku, Akira Watanabe, Junko Sato, Hideaki Hanaki, Naoya Masumori, Hiroshi Kiyota, Shin Egawa, Kazushi Tanaka, Soichi Arakawa, Masato FujisawaHiromi Kumon, Koichiro Wada, Kanao Kobayashi, Akio Matsubara, Tetsuro Matsumoto, Masatoshi Eto, Katsunori Tatsugami, Kentaro Kuroiwa, Kenji Ito, Takahide Hosobe, Hideo Hirayama, Harunori Narita, Takamasa Yamaguchi, Shin Ito, Toru Sumii, Shuichi Kawai, Mototsugu Kanokogi, Hiromi Kawano, Hirofumi Chokyu, Satoshi Uno, Koichi Monden, Shinichi Kaji, Motoshi Kawahara, Kazuo Takayama, Masayasu Ito, Masaru Yoshioka, Motonori Kano, Takatoshi Konishi, Hitoshi Kadena, Shohei Nishi, Hirofumi Nishimura, Takamine Yamauchi, Shinichi Maeda, Masanobu Horie, Hideari Ihara, Masaru Matsumura, Takeshi Shirane, Koh Takeyama, Kikuo Akiyama, Koichi Takahashi, Toshihiro Ikuyama, Hisato Inatomi, Mutsumasa Yoh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Genital chlamydial infection is a principal sexually transmitted infection worldwide. Chlamydia trachomatis can cause male urethritis, acute epididymitis, cervicitis, and pelvic inflammatory disease as sexually transmitted infections. Fortunately, homotypic resistant C. trachomatis strains have not been isolated to date; however, several studies have reported the isolation of heterotypic resistant strains from patients. In this surveillance study, clinical urethral discharge specimens were collected from patients with urethritis in 51 hospitals and clinics in 2009 and 38 in 2012. Based on serial cultures, the minimum inhibitory concentration (MIC) could be determined for 19 isolates in 2009 and 39 in 2012. In 2009 and 2012, the MICs (MIC90) of ciprofloxacin, levofloxacin, tosufloxacin, sitafloxacin, doxycycline, minocycline, erythromycin, clarithromycin, and azithromycin were 2 μg/ml and 1 μg/ml, 0.5 μg/ml and 0.5 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.063 μg/ml and 0.063 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.125 μg/ml and 0.125 μg/ml, 0.016 μg/ml and 0.016 μg/ml, and 0.063 μg/ml and 0.063 μg/ml, respectively. In summary, this surveillance project did not identify any resistant strain against fluoroquinolone, tetracycline, or macrolide agents in Japan.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalJournal of Infection and Chemotherapy
Volume22
Issue number9
DOIs
Publication statusPublished - 2016 Sep 1

Keywords

  • Antimicrobial susceptibility
  • Chlamydia trachomatis
  • Surveillance

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Takahashi, S., Hamasuna, R., Yasuda, M., Ishikawa, K., Hayami, H., Uehara, S., Yamamoto, S., Minamitani, S., Kadota, J., Iwata, S., Kaku, M., Watanabe, A., Sato, J., Hanaki, H., Masumori, N., Kiyota, H., Egawa, S., Tanaka, K., Arakawa, S., ... Yoh, M. (2016). Nationwide surveillance of the antimicrobial susceptibility of Chlamydia trachomatis from male urethritis in Japan. Journal of Infection and Chemotherapy, 22(9), 581-586. https://doi.org/10.1016/j.jiac.2016.06.010