Natriuretic peptide receptors in human artery and vein and rabbit vein graft

Tadashi Ikeda, Hiroshi Itoh, Yasato Komatsu, Michiya Hanyu, Takaaki Yoshimasa, Katsuhiko Matsuda, Kazuwa Nakao, Toshihiko Ban

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Natriuretic peptides elicit their biological effects by elevation of cGMP through activation of two biologically active receptors: natriuretic peptide A receptor, which shows high affinity to atrial and brain natriuretic peptides, and natriuretic peptide B receptor, which is specific to C-type natriuretic peptide. To elucidate the implications of the natriuretic peptide system in arteries and veins, we examined the cGMP production in response to atrial and C-type natriuretic peptides and gene expressions of biologically active natriuretic peptide receptors in human gastroepiploic artery, internal mammary artery, and saphenous vein. Atrial natriuretic peptide augmented cGMP production more potently by one order of magnitude in arteries than in veins. C-type natriuretic peptide stimulated cGMP production weakly and equally in these vessels. Analyzed by reverse transcription-polymerase chain reaction, gene expression of natriuretic peptide A receptor was four times more abundant in arteries than in veins. Gene expression of natriuretic peptide B receptor was approximately the same between these vessels. We also studied the responsiveness to atrial and C-type natriuretic peptide in rabbit jugular vein grafted into carotid artery. In arterialized vein grafts 4 weeks after operation, the effects of atrial and C-type natriuretic peptides on cGMP production did not change from those in jugular veins. In conclusion, atrial natriuretic peptide stimulates cGMP production more potently in arteries than in veins due to the preferential expression of natriuretic peptide A receptor in arteries. These observations support the distinct roles of natriuretic peptides in cardiovascular homeostasis.

Original languageEnglish
Pages (from-to)833-837
Number of pages5
JournalHypertension
Volume27
Issue number3 II
Publication statusPublished - 1996 Mar
Externally publishedYes

Fingerprint

Natriuretic Peptides
Peptide Receptors
C-Type Natriuretic Peptide
Atrial Natriuretic Factor
Veins
Arteries
Rabbits
Transplants
Jugular Veins
Gene Expression
Gastroepiploic Artery
Mammary Arteries
Brain Natriuretic Peptide
Saphenous Vein
Carotid Arteries
Reverse Transcription
Homeostasis
Polymerase Chain Reaction
peptide A

Keywords

  • cyclic GMP
  • natriuretic peptide
  • natriuretic peptide receptor
  • vein graft

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Ikeda, T., Itoh, H., Komatsu, Y., Hanyu, M., Yoshimasa, T., Matsuda, K., ... Ban, T. (1996). Natriuretic peptide receptors in human artery and vein and rabbit vein graft. Hypertension, 27(3 II), 833-837.

Natriuretic peptide receptors in human artery and vein and rabbit vein graft. / Ikeda, Tadashi; Itoh, Hiroshi; Komatsu, Yasato; Hanyu, Michiya; Yoshimasa, Takaaki; Matsuda, Katsuhiko; Nakao, Kazuwa; Ban, Toshihiko.

In: Hypertension, Vol. 27, No. 3 II, 03.1996, p. 833-837.

Research output: Contribution to journalArticle

Ikeda, T, Itoh, H, Komatsu, Y, Hanyu, M, Yoshimasa, T, Matsuda, K, Nakao, K & Ban, T 1996, 'Natriuretic peptide receptors in human artery and vein and rabbit vein graft', Hypertension, vol. 27, no. 3 II, pp. 833-837.
Ikeda T, Itoh H, Komatsu Y, Hanyu M, Yoshimasa T, Matsuda K et al. Natriuretic peptide receptors in human artery and vein and rabbit vein graft. Hypertension. 1996 Mar;27(3 II):833-837.
Ikeda, Tadashi ; Itoh, Hiroshi ; Komatsu, Yasato ; Hanyu, Michiya ; Yoshimasa, Takaaki ; Matsuda, Katsuhiko ; Nakao, Kazuwa ; Ban, Toshihiko. / Natriuretic peptide receptors in human artery and vein and rabbit vein graft. In: Hypertension. 1996 ; Vol. 27, No. 3 II. pp. 833-837.
@article{7d8b1dd0a2a545d28b153a1fcd07f556,
title = "Natriuretic peptide receptors in human artery and vein and rabbit vein graft",
abstract = "Natriuretic peptides elicit their biological effects by elevation of cGMP through activation of two biologically active receptors: natriuretic peptide A receptor, which shows high affinity to atrial and brain natriuretic peptides, and natriuretic peptide B receptor, which is specific to C-type natriuretic peptide. To elucidate the implications of the natriuretic peptide system in arteries and veins, we examined the cGMP production in response to atrial and C-type natriuretic peptides and gene expressions of biologically active natriuretic peptide receptors in human gastroepiploic artery, internal mammary artery, and saphenous vein. Atrial natriuretic peptide augmented cGMP production more potently by one order of magnitude in arteries than in veins. C-type natriuretic peptide stimulated cGMP production weakly and equally in these vessels. Analyzed by reverse transcription-polymerase chain reaction, gene expression of natriuretic peptide A receptor was four times more abundant in arteries than in veins. Gene expression of natriuretic peptide B receptor was approximately the same between these vessels. We also studied the responsiveness to atrial and C-type natriuretic peptide in rabbit jugular vein grafted into carotid artery. In arterialized vein grafts 4 weeks after operation, the effects of atrial and C-type natriuretic peptides on cGMP production did not change from those in jugular veins. In conclusion, atrial natriuretic peptide stimulates cGMP production more potently in arteries than in veins due to the preferential expression of natriuretic peptide A receptor in arteries. These observations support the distinct roles of natriuretic peptides in cardiovascular homeostasis.",
keywords = "cyclic GMP, natriuretic peptide, natriuretic peptide receptor, vein graft",
author = "Tadashi Ikeda and Hiroshi Itoh and Yasato Komatsu and Michiya Hanyu and Takaaki Yoshimasa and Katsuhiko Matsuda and Kazuwa Nakao and Toshihiko Ban",
year = "1996",
month = "3",
language = "English",
volume = "27",
pages = "833--837",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "3 II",

}

TY - JOUR

T1 - Natriuretic peptide receptors in human artery and vein and rabbit vein graft

AU - Ikeda, Tadashi

AU - Itoh, Hiroshi

AU - Komatsu, Yasato

AU - Hanyu, Michiya

AU - Yoshimasa, Takaaki

AU - Matsuda, Katsuhiko

AU - Nakao, Kazuwa

AU - Ban, Toshihiko

PY - 1996/3

Y1 - 1996/3

N2 - Natriuretic peptides elicit their biological effects by elevation of cGMP through activation of two biologically active receptors: natriuretic peptide A receptor, which shows high affinity to atrial and brain natriuretic peptides, and natriuretic peptide B receptor, which is specific to C-type natriuretic peptide. To elucidate the implications of the natriuretic peptide system in arteries and veins, we examined the cGMP production in response to atrial and C-type natriuretic peptides and gene expressions of biologically active natriuretic peptide receptors in human gastroepiploic artery, internal mammary artery, and saphenous vein. Atrial natriuretic peptide augmented cGMP production more potently by one order of magnitude in arteries than in veins. C-type natriuretic peptide stimulated cGMP production weakly and equally in these vessels. Analyzed by reverse transcription-polymerase chain reaction, gene expression of natriuretic peptide A receptor was four times more abundant in arteries than in veins. Gene expression of natriuretic peptide B receptor was approximately the same between these vessels. We also studied the responsiveness to atrial and C-type natriuretic peptide in rabbit jugular vein grafted into carotid artery. In arterialized vein grafts 4 weeks after operation, the effects of atrial and C-type natriuretic peptides on cGMP production did not change from those in jugular veins. In conclusion, atrial natriuretic peptide stimulates cGMP production more potently in arteries than in veins due to the preferential expression of natriuretic peptide A receptor in arteries. These observations support the distinct roles of natriuretic peptides in cardiovascular homeostasis.

AB - Natriuretic peptides elicit their biological effects by elevation of cGMP through activation of two biologically active receptors: natriuretic peptide A receptor, which shows high affinity to atrial and brain natriuretic peptides, and natriuretic peptide B receptor, which is specific to C-type natriuretic peptide. To elucidate the implications of the natriuretic peptide system in arteries and veins, we examined the cGMP production in response to atrial and C-type natriuretic peptides and gene expressions of biologically active natriuretic peptide receptors in human gastroepiploic artery, internal mammary artery, and saphenous vein. Atrial natriuretic peptide augmented cGMP production more potently by one order of magnitude in arteries than in veins. C-type natriuretic peptide stimulated cGMP production weakly and equally in these vessels. Analyzed by reverse transcription-polymerase chain reaction, gene expression of natriuretic peptide A receptor was four times more abundant in arteries than in veins. Gene expression of natriuretic peptide B receptor was approximately the same between these vessels. We also studied the responsiveness to atrial and C-type natriuretic peptide in rabbit jugular vein grafted into carotid artery. In arterialized vein grafts 4 weeks after operation, the effects of atrial and C-type natriuretic peptides on cGMP production did not change from those in jugular veins. In conclusion, atrial natriuretic peptide stimulates cGMP production more potently in arteries than in veins due to the preferential expression of natriuretic peptide A receptor in arteries. These observations support the distinct roles of natriuretic peptides in cardiovascular homeostasis.

KW - cyclic GMP

KW - natriuretic peptide

KW - natriuretic peptide receptor

KW - vein graft

UR - http://www.scopus.com/inward/record.url?scp=0029867245&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029867245&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 833

EP - 837

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 3 II

ER -