Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata

Kazuki Fujii; Yasumasa Hara; Midori A. Arai; Samir K. Sadhu; Firoj Ahmed; Masami Ishibashi

doi:10.1248/cpb.c22-00556

Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata

Kazuki Fujii, Yasumasa Hara, Midori A. Arai, Samir K. Sadhu, Firoj Ahmed, Masami Ishibashi

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

Abstract

A new coumarin derivative (1) and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata, guided by B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity. Among the isolated compounds, 15 compounds showed BMI1 promoter inhibitory activity, and five compounds were found to be cytotoxic. 14-Deoxy-11,12-dehydroandrographolide (18) was highly cytotoxic to DU145 cells with an IC₅₀ value of 25.4µM. Western blotting analysis of compound 18 in DU145 cells suggested that compound 18 suppresses BMI1 expression.

Original language	English
Pages (from-to)	885-891
Number of pages	7
Journal	Chemical and Pharmaceutical Bulletin
Volume	70
Issue number	12
DOIs	https://doi.org/10.1248/cpb.c22-00556
Publication status	Published - 2022 Dec 1

Keywords

Andrographis paniculata
B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity
Mammea siamensis
coumarin
labdane diterpene

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.c22-00556

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title = "Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata",

abstract = "A new coumarin derivative (1) and 30 known compounds were isolated from Mammea siamensis and Andrographis paniculata, guided by B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity. Among the isolated compounds, 15 compounds showed BMI1 promoter inhibitory activity, and five compounds were found to be cytotoxic. 14-Deoxy-11,12-dehydroandrographolide (18) was highly cytotoxic to DU145 cells with an IC50 value of 25.4µM. Western blotting analysis of compound 18 in DU145 cells suggested that compound 18 suppresses BMI1 expression.",

keywords = "Andrographis paniculata, B cell-specific Moloney murine leukemia virus insertion region 1 (BMI1) promoter inhibitory activity, Mammea siamensis, coumarin, labdane diterpene",

author = "Kazuki Fujii and Yasumasa Hara and Arai, {Midori A.} and Sadhu, {Samir K.} and Firoj Ahmed and Masami Ishibashi",

note = "Funding Information: We thank the late Takashi Koyano (Temko Corporation) and late Thaworn Kowithayakorn (Khon Kaen University) for their collaboration in the collection and identification of plant materials. This work was supported by KAKENHI (Grant Nos. 20H03394 and 20K16024) from the Japan Society for the Promotion of Science and JST SPRING (Grant No. JPMJSP2109). Publisher Copyright: {\textcopyright} 2022 The Pharmaceutical Society of Japan.",

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AU - Fujii, Kazuki

AU - Hara, Yasumasa

AU - Arai, Midori A.

AU - Sadhu, Samir K.

AU - Ahmed, Firoj

AU - Ishibashi, Masami

N1 - Funding Information: We thank the late Takashi Koyano (Temko Corporation) and late Thaworn Kowithayakorn (Khon Kaen University) for their collaboration in the collection and identification of plant materials. This work was supported by KAKENHI (Grant Nos. 20H03394 and 20K16024) from the Japan Society for the Promotion of Science and JST SPRING (Grant No. JPMJSP2109). Publisher Copyright: © 2022 The Pharmaceutical Society of Japan.

PY - 2022/12/1

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KW - labdane diterpene

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Natural Compounds with BMI1 Promoter Inhibitory Activity from Mammea siamensis and Andrographis paniculata

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