Natural compounds with Wnt signal modulating activity

Rolly G. Fuentes; Midori A. Arai; Masami Ishibashi

doi:10.1039/c5np00074b

Natural compounds with Wnt signal modulating activity

Rolly G. Fuentes, Midori A. Arai, Masami Ishibashi

Research output: Contribution to journal › Review article › peer-review

22 Citations (Scopus)

Abstract

Covering: up to 2015 The Wnt signalling pathway is essential in many biological processes. The Wnt signal is associated with several diseases, particularly cancer and neurodegenerative diseases. Recently, high-throughput screening systems have been developed to rapidly identify compounds, including natural compounds, that target the Wnt signal. Some studies on natural modulators of the Wnt signal have also suggested their possible target. This review highlights some important natural compounds reported to regulate Wnt activity and describes their possible mechanism of action.

Original language	English
Pages (from-to)	1622-1628
Number of pages	7
Journal	Natural Product Reports
Volume	32
Issue number	12
DOIs	https://doi.org/10.1039/c5np00074b
Publication status	Published - 2015 Dec
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1039/c5np00074b

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