@inbook{0bae1708788d4f12bcbc8ef70fe457dc,
title = "Natural Helper Cells. A New Player in the Innate Immune Response against Helminth Infection",
abstract = "The Th2-type immune response, characterized by the production of IL-4, IL-5, and IL-13, is a critical immune response against helminths invading cutaneous or mucosal sites. Th2 cytokines are induced soon after helminth infection, even before a pathogen-specific adaptive immune response is established. Although the expulsion and clearance of helminths usually requires pathogen-specific Th2-mediated immunity, early induction of Th2 cytokines during the innate immune phase is important for host protection from helminth invasion. Recent studies have shed light on such Th2 cytokine production by formerly uncharacterized innate immune cells such as a newly identified natural helper cell. We discuss here the mechanisms of innate production of Th2 cytokines in host immune responses against helminth infection.",
author = "Shigeo Koyasu and Kazuyo Moro and Masanobu Tanabe and Tsutomu Takeuchi",
note = "Funding Information: The authors wish to acknowledge the assistance of our collaborators, T. Yamada, T. Ikawa, H. Kawamoto, J.-I. Furusawa, M. Ohtani, and H. Fujii and members of our laboratories. We also thank for funding the Japan Society for the Promotion of Science: a Grant-in Aid for Young Scientist (B) (20790378 to K. M.), a Grant-in Aid for Young Scientist (A) (22689013 to K. M.), Grants-in-Aid for Scientific Research (B) (14370116, 16390146, 18390155 to S. K.), a Grant-in-Aid for Scientific Research (S) (22229004 to S. K.). The work was also supported by a Scientific Frontier Research Grant from the Ministry of Education, Culture, Sports, Science and Technology, Japan. K. M. is a postdoctoral fellow of the Global COE program supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan.",
year = "2010",
doi = "10.1016/B978-0-12-380995-7.00002-1",
language = "English",
series = "Advances in Immunology",
publisher = "Academic Press Inc.",
number = "C",
pages = "21--44",
booktitle = "Advances in Immunology",
address = "United States",
edition = "C",
}