Natural Helper Cells. A New Player in the Innate Immune Response against Helminth Infection

Shigeo Koyasu, Kazuyo Moro, Masanobu Tanabe, Tsutomu Takeuchi

Research output: Book/ReportBook

32 Citations (Scopus)

Abstract

The Th2-type immune response, characterized by the production of IL-4, IL-5, and IL-13, is a critical immune response against helminths invading cutaneous or mucosal sites. Th2 cytokines are induced soon after helminth infection, even before a pathogen-specific adaptive immune response is established. Although the expulsion and clearance of helminths usually requires pathogen-specific Th2-mediated immunity, early induction of Th2 cytokines during the innate immune phase is important for host protection from helminth invasion. Recent studies have shed light on such Th2 cytokine production by formerly uncharacterized innate immune cells such as a newly identified natural helper cell. We discuss here the mechanisms of innate production of Th2 cytokines in host immune responses against helminth infection.

Original languageEnglish
PublisherUnknown Publisher
Number of pages24
Volume108
EditionC
DOIs
Publication statusPublished - 2010

Publication series

NameAdvances in Immunology
No.C
Volume108
ISSN (Print)00652776
ISSN (Electronic)15578445

Fingerprint

Helminths
Helper-Inducer T-Lymphocytes
Innate Immunity
Cytokines
Infection
Interleukin-13
Interleukin-5
Adaptive Immunity
Interleukin-4
Immunity
Skin

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Koyasu, S., Moro, K., Tanabe, M., & Takeuchi, T. (2010). Natural Helper Cells. A New Player in the Innate Immune Response against Helminth Infection. (C ed.) (Advances in Immunology; Vol. 108, No. C). Unknown Publisher. https://doi.org/10.1016/B978-0-12-380995-7.00002-1

Natural Helper Cells. A New Player in the Innate Immune Response against Helminth Infection. / Koyasu, Shigeo; Moro, Kazuyo; Tanabe, Masanobu; Takeuchi, Tsutomu.

C ed. Unknown Publisher, 2010. 24 p. (Advances in Immunology; Vol. 108, No. C).

Research output: Book/ReportBook

Koyasu, S, Moro, K, Tanabe, M & Takeuchi, T 2010, Natural Helper Cells. A New Player in the Innate Immune Response against Helminth Infection. Advances in Immunology, no. C, vol. 108, vol. 108, C edn, Unknown Publisher. https://doi.org/10.1016/B978-0-12-380995-7.00002-1
Koyasu S, Moro K, Tanabe M, Takeuchi T. Natural Helper Cells. A New Player in the Innate Immune Response against Helminth Infection. C ed. Unknown Publisher, 2010. 24 p. (Advances in Immunology; C). https://doi.org/10.1016/B978-0-12-380995-7.00002-1
Koyasu, Shigeo ; Moro, Kazuyo ; Tanabe, Masanobu ; Takeuchi, Tsutomu. / Natural Helper Cells. A New Player in the Innate Immune Response against Helminth Infection. C ed. Unknown Publisher, 2010. 24 p. (Advances in Immunology; C).
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