Natural History and Prognosis of Adenomatous Hyperplasia and Early Hepatocellular Carcinoma

Multi-institutional Analysis of 53 Nodules Followed Up for More Than 6 Months and 141 Patients with Single Early Hepatocellular Carcinoma Treated by Surgical Resection or Percutaneous Ethanol Injection

Michiie Sakamoto, Setsuo Hirohashi

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Background: The natural history and posttherapeutic outcome of adenomatous hyperplasia and early hepatocellular carcinoma have rarely been analyzed. Methods: Fifty-three hepatic tumors diagnosed as adenomatous hyperplasia or early hepatocellular carcinoma and followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or ethanol injection were collected retrospectively and analyzed. Results: Some of the adenomatous hyperplasias developed to early and to advanced hepatocellular carcinoma. Tumors tended to grow faster in the order adenomatous hyperplasia, early hepatocellular carcinoma and advanced hepatocellular carcinoma, with respective mean (SD) tumor volume doubling times of 21.2 (10.7), 13.9 (11.7) and 6.0 (5.2) months. Overall survival rates at 5 years in 53 patients treated by surgery and 88 patients treated by ethanol injection were 89.6 and 71.9%, respectively. Conclusion: Progression of adenomatous hyperplasia and early HCC was confirmed pathologically. Early HCC was shown to have a good prognosis.

Original languageEnglish
Pages (from-to)604-608
Number of pages5
JournalJapanese Journal of Clinical Oncology
Volume28
Issue number10
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Natural History
Hyperplasia
Hepatocellular Carcinoma
Ethanol
Injections
Tumor Burden
Neoplasms
Survival Rate
Liver

Keywords

  • Adenomatous hyperplasia
  • Hepatocellular carcinoma
  • Prognosis
  • Tumor progression

ASJC Scopus subject areas

  • Oncology

Cite this

@article{f5c5e5a29eb841478288bff4b3773231,
title = "Natural History and Prognosis of Adenomatous Hyperplasia and Early Hepatocellular Carcinoma: Multi-institutional Analysis of 53 Nodules Followed Up for More Than 6 Months and 141 Patients with Single Early Hepatocellular Carcinoma Treated by Surgical Resection or Percutaneous Ethanol Injection",
abstract = "Background: The natural history and posttherapeutic outcome of adenomatous hyperplasia and early hepatocellular carcinoma have rarely been analyzed. Methods: Fifty-three hepatic tumors diagnosed as adenomatous hyperplasia or early hepatocellular carcinoma and followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or ethanol injection were collected retrospectively and analyzed. Results: Some of the adenomatous hyperplasias developed to early and to advanced hepatocellular carcinoma. Tumors tended to grow faster in the order adenomatous hyperplasia, early hepatocellular carcinoma and advanced hepatocellular carcinoma, with respective mean (SD) tumor volume doubling times of 21.2 (10.7), 13.9 (11.7) and 6.0 (5.2) months. Overall survival rates at 5 years in 53 patients treated by surgery and 88 patients treated by ethanol injection were 89.6 and 71.9{\%}, respectively. Conclusion: Progression of adenomatous hyperplasia and early HCC was confirmed pathologically. Early HCC was shown to have a good prognosis.",
keywords = "Adenomatous hyperplasia, Hepatocellular carcinoma, Prognosis, Tumor progression",
author = "Michiie Sakamoto and Setsuo Hirohashi",
year = "1998",
language = "English",
volume = "28",
pages = "604--608",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Natural History and Prognosis of Adenomatous Hyperplasia and Early Hepatocellular Carcinoma

T2 - Multi-institutional Analysis of 53 Nodules Followed Up for More Than 6 Months and 141 Patients with Single Early Hepatocellular Carcinoma Treated by Surgical Resection or Percutaneous Ethanol Injection

AU - Sakamoto, Michiie

AU - Hirohashi, Setsuo

PY - 1998

Y1 - 1998

N2 - Background: The natural history and posttherapeutic outcome of adenomatous hyperplasia and early hepatocellular carcinoma have rarely been analyzed. Methods: Fifty-three hepatic tumors diagnosed as adenomatous hyperplasia or early hepatocellular carcinoma and followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or ethanol injection were collected retrospectively and analyzed. Results: Some of the adenomatous hyperplasias developed to early and to advanced hepatocellular carcinoma. Tumors tended to grow faster in the order adenomatous hyperplasia, early hepatocellular carcinoma and advanced hepatocellular carcinoma, with respective mean (SD) tumor volume doubling times of 21.2 (10.7), 13.9 (11.7) and 6.0 (5.2) months. Overall survival rates at 5 years in 53 patients treated by surgery and 88 patients treated by ethanol injection were 89.6 and 71.9%, respectively. Conclusion: Progression of adenomatous hyperplasia and early HCC was confirmed pathologically. Early HCC was shown to have a good prognosis.

AB - Background: The natural history and posttherapeutic outcome of adenomatous hyperplasia and early hepatocellular carcinoma have rarely been analyzed. Methods: Fifty-three hepatic tumors diagnosed as adenomatous hyperplasia or early hepatocellular carcinoma and followed up for more than 6 months and 141 patients with single early hepatocellular carcinoma treated by surgical resection or ethanol injection were collected retrospectively and analyzed. Results: Some of the adenomatous hyperplasias developed to early and to advanced hepatocellular carcinoma. Tumors tended to grow faster in the order adenomatous hyperplasia, early hepatocellular carcinoma and advanced hepatocellular carcinoma, with respective mean (SD) tumor volume doubling times of 21.2 (10.7), 13.9 (11.7) and 6.0 (5.2) months. Overall survival rates at 5 years in 53 patients treated by surgery and 88 patients treated by ethanol injection were 89.6 and 71.9%, respectively. Conclusion: Progression of adenomatous hyperplasia and early HCC was confirmed pathologically. Early HCC was shown to have a good prognosis.

KW - Adenomatous hyperplasia

KW - Hepatocellular carcinoma

KW - Prognosis

KW - Tumor progression

UR - http://www.scopus.com/inward/record.url?scp=0032187919&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032187919&partnerID=8YFLogxK

M3 - Article

VL - 28

SP - 604

EP - 608

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 10

ER -