Natural killer T cells in adipose tissue are activated in lean mice

Taisuke Kondo, Yujiro Toyoshima, Yoshiyuki Ishii, Shigeru Kyuwa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Adipose tissues are closely connected with the immune system. It has been suggested that metabolic syndromes such as type 2 diabetes, arteriosclerosis and liver steatosis can be attributed to adipose tissue inflammation characterized by macrophage infiltration. To understand a physiological and pathological role of natural killer T (NKT) cells on inflammation in adipose tissue, we characterized a subset of NKT cells in abdominal and subcutaneous adipose tissues in C57BL/6J mice fed normal or high-fat diets. NKT cells comprised a larger portion of lymphocytes in adipose tissues compared with the spleen and peripheral blood, with epididymal adipose tissue having the highest number of NKT cells. Furthermore, some NKT cells in adipose tissues expressed higher levels of CD69 and intracellular interferon-γ, whereas the Vβ repertoires of NKT cells in adipose tissues were similar to other cells. In obese mice fed a high-fat diet, adipose tissue inflammation had little effect on the Vβ repertoire of NKT cells in epididymal adipose tissues. We speculate that the NKT cells in adipose tissues may form an equivalent subset in other tissues and that these subsets are likely to participate in adipose tissue inflammation. Additionally, the high expression level of CD69 and intracellular IFN-γ raises the possibility that NKT cells in adipose tissue may be stimulated by some physiological mechanism.

Original languageEnglish
Pages (from-to)319-328
Number of pages10
JournalExperimental Animals
Volume62
Issue number4
DOIs
Publication statusPublished - 2013 Oct 31
Externally publishedYes

Fingerprint

Natural Killer T-Cells
T-cells
natural killer cells
adipose tissue
Adipose Tissue
T-lymphocytes
Tissue
mice
inflammation
Inflammation
High Fat Diet
high fat diet
Nutrition
Abdominal Subcutaneous Fat
Fats
Obese Mice
Arteriosclerosis
Fatty Liver
fatty liver
metabolic syndrome

Keywords

  • Adipose tissue
  • Diet induced obesity
  • NKT cell
  • Repertoire

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Natural killer T cells in adipose tissue are activated in lean mice. / Kondo, Taisuke; Toyoshima, Yujiro; Ishii, Yoshiyuki; Kyuwa, Shigeru.

In: Experimental Animals, Vol. 62, No. 4, 31.10.2013, p. 319-328.

Research output: Contribution to journalArticle

Kondo, T, Toyoshima, Y, Ishii, Y & Kyuwa, S 2013, 'Natural killer T cells in adipose tissue are activated in lean mice', Experimental Animals, vol. 62, no. 4, pp. 319-328. https://doi.org/10.1538/expanim.62.319
Kondo, Taisuke ; Toyoshima, Yujiro ; Ishii, Yoshiyuki ; Kyuwa, Shigeru. / Natural killer T cells in adipose tissue are activated in lean mice. In: Experimental Animals. 2013 ; Vol. 62, No. 4. pp. 319-328.
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