TY - JOUR
T1 - Near-field fluorescence correlation spectroscopy using a fiber probe
AU - Suzuki, Motohiko
AU - Saiki, Toshiharu
PY - 2009/7/1
Y1 - 2009/7/1
N2 - We have developed a new technique for fluorescence correlation spectroscopy (FCS) using an optical fiber probe, as is employed in nearfield scanning optical microscopy under the illumination-collection hybrid mode. A small observation volume beyond the diffraction limit makes it possible to apply FCS to concentrated solutions with high spatial resolution. Owing to the large transmission efficiency of the probe, correlation traces with an adequate signal-to-noise ratio resulted. We performed FCS measurements for fluorescent particles to demonstrate the validity of the method.
AB - We have developed a new technique for fluorescence correlation spectroscopy (FCS) using an optical fiber probe, as is employed in nearfield scanning optical microscopy under the illumination-collection hybrid mode. A small observation volume beyond the diffraction limit makes it possible to apply FCS to concentrated solutions with high spatial resolution. Owing to the large transmission efficiency of the probe, correlation traces with an adequate signal-to-noise ratio resulted. We performed FCS measurements for fluorescent particles to demonstrate the validity of the method.
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U2 - 10.1143/JJAP.48.070209
DO - 10.1143/JJAP.48.070209
M3 - Article
AN - SCOPUS:72049128601
SN - 0021-4922
VL - 48
JO - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes
JF - Japanese Journal of Applied Physics, Part 1: Regular Papers & Short Notes
IS - 7 PART 1
M1 - 070209
ER -