Near-field fluorescence correlation spectroscopy using a fiber probe

Motohiko Suzuki, Toshiharu Saiki

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Abstract

We have developed a new technique for fluorescence correlation spectroscopy (FCS) using an optical fiber probe, as is employed in nearfield scanning optical microscopy under the illumination-collection hybrid mode. A small observation volume beyond the diffraction limit makes it possible to apply FCS to concentrated solutions with high spatial resolution. Owing to the large transmission efficiency of the probe, correlation traces with an adequate signal-to-noise ratio resulted. We performed FCS measurements for fluorescent particles to demonstrate the validity of the method.

Original languageEnglish
Article number070209
JournalJapanese journal of applied physics
Volume48
Issue number7 PART 1
DOIs
Publication statusPublished - 2009 Jul 1

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ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

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