Near-infrared femtosecond laser-triggered nanoperforation of hollow microcapsules

Mitsuhiro Terakawa, Tatsuki Mitsuhashi, Takuya Shinohara, Hisashi Shimizu

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Fabrication of a nanopore in a hollow microcapsule was demonstrated using near-infrared femtosecond laser irradiation. The shape of the irradiated microcapsules was kept spherical except for a pore in the shell owing to the nonthermal processing by a femtosecond laser. The simulation results for the near-field and far-field scattering around a microcapsule revealed that highly-enhanced optical intensity can be generated at a spot on the shell of a microcapsule, which would in turn contribute to localized ablation. To the best of our knowledge, this is the first demonstration of the nanoperforation of transparent hollow microcapsules by a near-infrared laser without any doping with absorbing metals or dyes that may cause cell toxicity. The presented method is a promising approach for safer drug delivery and the controlled release of therapeutic drugs.

    Original languageEnglish
    Pages (from-to)12604-12610
    Number of pages7
    JournalOptics Express
    Volume21
    Issue number10
    DOIs
    Publication statusPublished - 2013 May 20

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics

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