Near-infrared light propagation in an adult head model. I. Modeling of low-level scattering in the cerebrospinal fluid layer

Eiji Okada, David T. Delpy

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

Adequate modeling of light propagation in a human head is important for quantitative near-infrared spectroscopy and optical imaging. The presence of a nonscattering cerebrospinal fluid (CSF) that surrounds the brain has been previously shown to have a strong effect on light propagation in the head. However, in reality, a small amount of scattering is caused by the arachnoid trabeculae in the CSF layer. In this study, light propagation in an adult head model with discrete scatterers distributed within the CSF layer has been predicted by Monte Carlo simulation to investigate the effect of the small amount of scattering caused by the arachnoid trabeculae in the CSF layer. This low scattering in the CSF layer is found to have little effect on the mean optical path length, a parameter that can be directly measured by a time-resolved experiment. However, the partial optical path length in brain tissue that relates the sensitivity of the detected signal to absorption changes in the brain is strongly affected by the presence of scattering within the CSF layer. The sensitivity of the near-infrared signal to hemoglobin changes induced by brain activation is improved by the effect of a low-scattering CSF layer.

Original languageEnglish
Pages (from-to)2906-2914
Number of pages9
JournalApplied Optics
Volume42
Issue number16
Publication statusPublished - 2003 Jun 1

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cerebrospinal fluid
Cerebrospinal fluid
Light propagation
Scattering
Infrared radiation
propagation
brain
scattering
Brain
optical paths
Near infrared spectroscopy
sensitivity
Hemoglobin
hemoglobin
Chemical activation
infrared spectroscopy
activation
Tissue
Imaging techniques

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Near-infrared light propagation in an adult head model. I. Modeling of low-level scattering in the cerebrospinal fluid layer. / Okada, Eiji; Delpy, David T.

In: Applied Optics, Vol. 42, No. 16, 01.06.2003, p. 2906-2914.

Research output: Contribution to journalArticle

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