Near Infrared Light-Triggerd on-Demand Drug Delivery from Non-Toxic Hydrogel Microbeads with Heat Transducer

Shuhei Takatsuka, Takeshi Kubota, Yuta Kurashina, Hiroaki Onoe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes a near-infrared (NIR) light-triggered drug release system using alginate hydrogel microbeads. As a drug carrier, calcium alginate hydrogel microbeads encapsulating heat transducing particle (Fe304 particles) were fabricated by a centrifugal based fabrication method. The Fe304 particles instantly generate heat due to localized surface plasmon resonance when irradiated with NIR light. As a result, the calcium alginate hydrogel is thermally denatured to release a drug model. By irradiating NIR-laser to the hydrogel microbeads, we confirmed the release of fluorescent polystyrene particles ( 10 nm) as a drug model. This result indicates that the polymer network of the calcium alginate hydrogel responded to the heat at the molecular scale, even though calcium alginate hydrogel is generally stable to heat. This NIR light-triggered drug release system using Fe3O4 particles would be an effectiveand safe platform for on-demand drug delivery.

Original languageEnglish
Title of host publication21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1000-1003
Number of pages4
ISBN (Electronic)9781665412674
DOIs
Publication statusPublished - 2021 Jun 20
Event21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021 - Virtual, Online, United States
Duration: 2021 Jun 202021 Jun 25

Publication series

Name21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021

Conference

Conference21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
Country/TerritoryUnited States
CityVirtual, Online
Period21/6/2021/6/25

Keywords

  • Calcium alginate
  • Drug release
  • Hydrogel microbeads
  • Near-infrared laser
  • NIR

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Control and Optimization
  • Instrumentation

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