Near-infrared spectroscopic measurement of fat in the myocardial optical phantom

Takuma Hibi, Keito Yasumoto, Emiyu Ogawa, Tsunenori Arai

Research output: Contribution to journalArticle

Abstract

We studied the relation between the fat ratio in optical phantoms and near-infrared spectrum for multivariate analysis to develop a detection method of ganglionated plexuses in epicardial fat under catheter intervention. The optical phantoms of human myocardial tissue were made from water, agar, and triglyceride. The spectrum of back-scattering light was measured by an optical fiber in water or pig blood. We investigated the relation between the fat ratio and peak areas, using spectrum in 1000~1500 nm, its 1<sup>st</sup>, and 2<sup>nd</sup> derivative spectrum. The determinated coefficients were 0.97 and 0.99, respectively. We obtained a method to estimate the fat ratio of optical phantoms [%] ex vivo with error under 1.99 and 1.37 [%], respectively. According to the publications and our results, we calculated epicardial fat thickness with an accuracy of 0.20 and 0.14 [mm], respectively. In conclusion, we predicted that we might detect ganglionated plexuses by measurement of the fat ratio in vivo.

Original languageEnglish
Pages (from-to)O-454
JournalTransactions of Japanese Society for Medical and Biological Engineering
Volume52
DOIs
Publication statusPublished - 2014 Aug 17

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Keywords

  • Fat
  • Ganglionated plexuses
  • Near-infrared
  • Phantom
  • Spectroscopy

ASJC Scopus subject areas

  • Biomedical Engineering

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