Near-infrared spectroscopy system with non-contact source and detector for in vivo multi-distance measurement of deep biological tissue

Tsukasa Funane, Hirokazu Atsumori, Masashi Kiguchi, Yukari Tanikawa, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

A non-contact near-infrared spectroscopy (NIRS) scanning system with a phosphor cell placed on the skin for in vivo measurement of biological tissue was developed and evaluated. Because the phosphor is excited by the light that propagates in the tissue, and the excitation light is cut by optical filters, the light that propagates in the tissue is selectively detected. The non-contact system was extended to create a scanning system that can flexibly change source positions with a galvano scanner. The optical scanning system was used for non-contact measurement of the human forearm muscle, and the dependence of optical-density change (ΔOD) caused by the upper-arm occlusion and release on source-detector distance was observed. The obtained ΔOD demonstrates the effectiveness of using this system for multi-distance human-forearm measurement. Furthermore, a human forehead was measured with the system. To extract a deep-layer signal, a surface-layer subtraction method with short-distance regression was applied to measured data. On the basis of the correlation with a simultaneously measured laser-Doppler flowmetry signal, it was confirmed that the deep-layer signal was successfully extracted. The extraction result demonstrates that the optical scanning system can be used as a multi-distance NIRS system for measuring the human brain activity at the forehead.

Original languageEnglish
Title of host publicationOptical Tomography and Spectroscopy of Tissue X
DOIs
Publication statusPublished - 2013 May 27
EventOptical Tomography and Spectroscopy of Tissue X - San Francisco, CA, United States
Duration: 2013 Feb 32013 Feb 6

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8578
ISSN (Print)1605-7422

Other

OtherOptical Tomography and Spectroscopy of Tissue X
CountryUnited States
CitySan Francisco, CA
Period13/2/313/2/6

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Keywords

  • Near-infrared spectroscopy (NIRS)
  • biological tissue
  • brain
  • multi-distance
  • muscle
  • non-contact
  • phosphor
  • scanning system

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Cite this

Funane, T., Atsumori, H., Kiguchi, M., Tanikawa, Y., & Okada, E. (2013). Near-infrared spectroscopy system with non-contact source and detector for in vivo multi-distance measurement of deep biological tissue. In Optical Tomography and Spectroscopy of Tissue X [85782W] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8578). https://doi.org/10.1117/12.2002254