Necrotizing tracheobronchitis in patent ductus arteriosus-dependent cyanotic congenital heart disease

Yuji Nakata, Yoshiyuki Morikawa, Masaru Miura, Kazuki Kawasaki, Hiroshi Toyoma, Kaori Kameyama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report 2 patients with necrotizing tracheobronchitis (NTB) associated with patent ductus arteriosus-dependent cyanotic congenital heart disease. The pathologic findings suggest that hypotension and decreased tracheo-bronchial perfusion were the major contributing factors in the development of NTB. Necrotizing tracheobronchitis developed in infants with pulmonary atresia and Ebstein's anomaly with pulmonary stenosis. Both infants required prostaglandin E1 infusion from early infancy, and presented with sudden onset of dyspnea and hypercapnea. In one infant, NTB developed prior to mechanical ventilation. In the other infant, NTB developed after 4 days of mechanical ventilation. Care of both infants involved minimal pressures and FiO2, adequate humidification, and optimal temperature of inspired gases; these factors probably did not play a role in the development or worsening of NTB. Both infants had hypotension and hypoxemia. These factors could have contributed to the development of NTB because of decreased perfusion pressure and tissue hypoxia. As the area of necrosis and its severity correlated with the area of blood supply served by the specific feeding arteries, we speculate that tissue hypoperfusion was the major cause of NTB.

Original languageEnglish
Pages (from-to)480-483
Number of pages4
JournalPediatric Pulmonology
Volume32
Issue number6
DOIs
Publication statusPublished - 2001

Fingerprint

Patent Ductus Arteriosus
Heart Diseases
Artificial Respiration
Hypotension
Perfusion
Ebstein Anomaly
Pulmonary Atresia
Infant Care
Pressure
Pulmonary Valve Stenosis
Alprostadil
Dyspnea
Necrosis
Arteries
Gases
Temperature

Keywords

  • Ebstein's anomaly
  • Hypotension
  • Patent ductus arteriosus
  • PDA-dependent congenital heart disease
  • Tracheo-bronchial hypoperfusion
  • Tracheobronchitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Necrotizing tracheobronchitis in patent ductus arteriosus-dependent cyanotic congenital heart disease. / Nakata, Yuji; Morikawa, Yoshiyuki; Miura, Masaru; Kawasaki, Kazuki; Toyoma, Hiroshi; Kameyama, Kaori.

In: Pediatric Pulmonology, Vol. 32, No. 6, 2001, p. 480-483.

Research output: Contribution to journalArticle

Nakata, Yuji ; Morikawa, Yoshiyuki ; Miura, Masaru ; Kawasaki, Kazuki ; Toyoma, Hiroshi ; Kameyama, Kaori. / Necrotizing tracheobronchitis in patent ductus arteriosus-dependent cyanotic congenital heart disease. In: Pediatric Pulmonology. 2001 ; Vol. 32, No. 6. pp. 480-483.
@article{73d77087328d4f8f9c087f5a5e0bd598,
title = "Necrotizing tracheobronchitis in patent ductus arteriosus-dependent cyanotic congenital heart disease",
abstract = "We report 2 patients with necrotizing tracheobronchitis (NTB) associated with patent ductus arteriosus-dependent cyanotic congenital heart disease. The pathologic findings suggest that hypotension and decreased tracheo-bronchial perfusion were the major contributing factors in the development of NTB. Necrotizing tracheobronchitis developed in infants with pulmonary atresia and Ebstein's anomaly with pulmonary stenosis. Both infants required prostaglandin E1 infusion from early infancy, and presented with sudden onset of dyspnea and hypercapnea. In one infant, NTB developed prior to mechanical ventilation. In the other infant, NTB developed after 4 days of mechanical ventilation. Care of both infants involved minimal pressures and FiO2, adequate humidification, and optimal temperature of inspired gases; these factors probably did not play a role in the development or worsening of NTB. Both infants had hypotension and hypoxemia. These factors could have contributed to the development of NTB because of decreased perfusion pressure and tissue hypoxia. As the area of necrosis and its severity correlated with the area of blood supply served by the specific feeding arteries, we speculate that tissue hypoperfusion was the major cause of NTB.",
keywords = "Ebstein's anomaly, Hypotension, Patent ductus arteriosus, PDA-dependent congenital heart disease, Tracheo-bronchial hypoperfusion, Tracheobronchitis",
author = "Yuji Nakata and Yoshiyuki Morikawa and Masaru Miura and Kazuki Kawasaki and Hiroshi Toyoma and Kaori Kameyama",
year = "2001",
doi = "10.1002/ppul.1162",
language = "English",
volume = "32",
pages = "480--483",
journal = "Pediatric Pulmonology",
issn = "8755-6863",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Necrotizing tracheobronchitis in patent ductus arteriosus-dependent cyanotic congenital heart disease

AU - Nakata, Yuji

AU - Morikawa, Yoshiyuki

AU - Miura, Masaru

AU - Kawasaki, Kazuki

AU - Toyoma, Hiroshi

AU - Kameyama, Kaori

PY - 2001

Y1 - 2001

N2 - We report 2 patients with necrotizing tracheobronchitis (NTB) associated with patent ductus arteriosus-dependent cyanotic congenital heart disease. The pathologic findings suggest that hypotension and decreased tracheo-bronchial perfusion were the major contributing factors in the development of NTB. Necrotizing tracheobronchitis developed in infants with pulmonary atresia and Ebstein's anomaly with pulmonary stenosis. Both infants required prostaglandin E1 infusion from early infancy, and presented with sudden onset of dyspnea and hypercapnea. In one infant, NTB developed prior to mechanical ventilation. In the other infant, NTB developed after 4 days of mechanical ventilation. Care of both infants involved minimal pressures and FiO2, adequate humidification, and optimal temperature of inspired gases; these factors probably did not play a role in the development or worsening of NTB. Both infants had hypotension and hypoxemia. These factors could have contributed to the development of NTB because of decreased perfusion pressure and tissue hypoxia. As the area of necrosis and its severity correlated with the area of blood supply served by the specific feeding arteries, we speculate that tissue hypoperfusion was the major cause of NTB.

AB - We report 2 patients with necrotizing tracheobronchitis (NTB) associated with patent ductus arteriosus-dependent cyanotic congenital heart disease. The pathologic findings suggest that hypotension and decreased tracheo-bronchial perfusion were the major contributing factors in the development of NTB. Necrotizing tracheobronchitis developed in infants with pulmonary atresia and Ebstein's anomaly with pulmonary stenosis. Both infants required prostaglandin E1 infusion from early infancy, and presented with sudden onset of dyspnea and hypercapnea. In one infant, NTB developed prior to mechanical ventilation. In the other infant, NTB developed after 4 days of mechanical ventilation. Care of both infants involved minimal pressures and FiO2, adequate humidification, and optimal temperature of inspired gases; these factors probably did not play a role in the development or worsening of NTB. Both infants had hypotension and hypoxemia. These factors could have contributed to the development of NTB because of decreased perfusion pressure and tissue hypoxia. As the area of necrosis and its severity correlated with the area of blood supply served by the specific feeding arteries, we speculate that tissue hypoperfusion was the major cause of NTB.

KW - Ebstein's anomaly

KW - Hypotension

KW - Patent ductus arteriosus

KW - PDA-dependent congenital heart disease

KW - Tracheo-bronchial hypoperfusion

KW - Tracheobronchitis

UR - http://www.scopus.com/inward/record.url?scp=0035204177&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035204177&partnerID=8YFLogxK

U2 - 10.1002/ppul.1162

DO - 10.1002/ppul.1162

M3 - Article

VL - 32

SP - 480

EP - 483

JO - Pediatric Pulmonology

JF - Pediatric Pulmonology

SN - 8755-6863

IS - 6

ER -