Abstract
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The cytokine-inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. This article focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 205-220 |
| Number of pages | 16 |
| Journal | Clinical Reviews in Allergy and Immunology |
| Volume | 28 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2005 Jun |
| Externally published | Yes |
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Keywords
- Cytokine
- NF-κB
- STAT
- Toll-like receptor family
- Tyrosine kinase
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Negative regulation of cytokine signaling. / Yoshimura, Akihiko.
In: Clinical Reviews in Allergy and Immunology, Vol. 28, No. 3, 06.2005, p. 205-220.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Negative regulation of cytokine signaling
AU - Yoshimura, Akihiko
PY - 2005/6
Y1 - 2005/6
N2 - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The cytokine-inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. This article focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases.
AB - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The cytokine-inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. This article focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases.
KW - Cytokine
KW - NF-κB
KW - STAT
KW - Toll-like receptor family
KW - Tyrosine kinase
UR - http://www.scopus.com/inward/record.url?scp=23944480863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23944480863&partnerID=8YFLogxK
U2 - 10.1385/CRIAI:28:3:205
DO - 10.1385/CRIAI:28:3:205
M3 - Article
C2 - 16129905
AN - SCOPUS:23944480863
VL - 28
SP - 205
EP - 220
JO - Clinical reviews in allergy & immunology
JF - Clinical reviews in allergy & immunology
SN - 1080-0549
IS - 3
ER -