Negative regulation of cytokine signaling

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The cytokine-inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. This article focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases.

Original languageEnglish
Pages (from-to)205-220
Number of pages16
JournalClinical Reviews in Allergy and Immunology
Volume28
Issue number3
DOIs
Publication statusPublished - 2005 Jun
Externally publishedYes

Fingerprint

Cytokines
Suppressor of Cytokine Signaling Proteins
Janus Kinases
Interleukins
Adaptive Immunity
Transducers
Innate Immunity
Interferons
Immune System
Proteins
Homeostasis
Transcription Factors

Keywords

  • Cytokine
  • NF-κB
  • STAT
  • Toll-like receptor family
  • Tyrosine kinase

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Negative regulation of cytokine signaling. / Yoshimura, Akihiko.

In: Clinical Reviews in Allergy and Immunology, Vol. 28, No. 3, 06.2005, p. 205-220.

Research output: Contribution to journalArticle

@article{55c772d5706d4a9a83e0e2945e1f9064,
title = "Negative regulation of cytokine signaling",
abstract = "Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The cytokine-inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. This article focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases.",
keywords = "Cytokine, NF-κB, STAT, Toll-like receptor family, Tyrosine kinase",
author = "Akihiko Yoshimura",
year = "2005",
month = "6",
doi = "10.1385/CRIAI:28:3:205",
language = "English",
volume = "28",
pages = "205--220",
journal = "Clinical reviews in allergy & immunology",
issn = "1080-0549",
publisher = "Humana Press",
number = "3",

}

TY - JOUR

T1 - Negative regulation of cytokine signaling

AU - Yoshimura, Akihiko

PY - 2005/6

Y1 - 2005/6

N2 - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The cytokine-inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. This article focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases.

AB - Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The cytokine-inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. This article focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases.

KW - Cytokine

KW - NF-κB

KW - STAT

KW - Toll-like receptor family

KW - Tyrosine kinase

UR - http://www.scopus.com/inward/record.url?scp=23944480863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23944480863&partnerID=8YFLogxK

U2 - 10.1385/CRIAI:28:3:205

DO - 10.1385/CRIAI:28:3:205

M3 - Article

C2 - 16129905

AN - SCOPUS:23944480863

VL - 28

SP - 205

EP - 220

JO - Clinical reviews in allergy & immunology

JF - Clinical reviews in allergy & immunology

SN - 1080-0549

IS - 3

ER -