Negative regulation of cytokine signaling and immune responses by SOCS proteins

Akihiko Yoshimura, Hitomi Nishinakamura, Yumiko Matsumura, Toshikatsu Hanada

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through JAKs (Janus tyrosine kinases) and STAT (signal transduction and activators of transcription) transcription factors. CIS (cytokine-inducible SH2 (Src homology 2) protein) and SOCS (suppressor of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine-mediated homeostasis, including innate and adaptive immunity. In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis.

Original languageEnglish
Pages (from-to)100-110
Number of pages11
JournalArthritis Research and Therapy
Volume7
Issue number3
DOIs
Publication statusPublished - 2005 Jun
Externally publishedYes

Fingerprint

Suppressor of Cytokine Signaling Proteins
Cytokines
Janus Kinases
Interleukins
Adaptive Immunity
Innate Immunity
Protein-Tyrosine Kinases
Interferons
Immune System
Signal Transduction
Rheumatoid Arthritis
Homeostasis
Transcription Factors
Proteins

ASJC Scopus subject areas

  • Rheumatology

Cite this

Negative regulation of cytokine signaling and immune responses by SOCS proteins. / Yoshimura, Akihiko; Nishinakamura, Hitomi; Matsumura, Yumiko; Hanada, Toshikatsu.

In: Arthritis Research and Therapy, Vol. 7, No. 3, 06.2005, p. 100-110.

Research output: Contribution to journalArticle

Yoshimura, Akihiko ; Nishinakamura, Hitomi ; Matsumura, Yumiko ; Hanada, Toshikatsu. / Negative regulation of cytokine signaling and immune responses by SOCS proteins. In: Arthritis Research and Therapy. 2005 ; Vol. 7, No. 3. pp. 100-110.
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