Negative regulation of cytokine signaling and inflammatory diseases

Kyoko Inagaki-Ohara, Toshikatsu Hanada, Akihiko Yoshimura

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activators of transcription (STATs). The cytokine-inducible SH2 proteins (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory system. Several recent advances have been made in this field, including treatment of inflammatory diseases by modulating extracellular and intracellular signaling pathways.

Original languageEnglish
Pages (from-to)435-442
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume3
Issue number4
DOIs
Publication statusPublished - 2003 Aug
Externally publishedYes

Fingerprint

Cytokines
Suppressor of Cytokine Signaling Proteins
Janus Kinases
Interleukins
Transducers
Protein-Tyrosine Kinases
Interferons
Immune System
Proteins

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Negative regulation of cytokine signaling and inflammatory diseases. / Inagaki-Ohara, Kyoko; Hanada, Toshikatsu; Yoshimura, Akihiko.

In: Current Opinion in Pharmacology, Vol. 3, No. 4, 08.2003, p. 435-442.

Research output: Contribution to journalArticle

Inagaki-Ohara, Kyoko ; Hanada, Toshikatsu ; Yoshimura, Akihiko. / Negative regulation of cytokine signaling and inflammatory diseases. In: Current Opinion in Pharmacology. 2003 ; Vol. 3, No. 4. pp. 435-442.
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