Negative regulation of cytokine signaling by CIS/SOCS family proteins and their roles in inflammatory diseases.

T. Hanada, I. Kinjyo, K. Inagaki-Ohara, A. Yoshimura

Research output: Contribution to journalReview article

31 Citations (Scopus)


Immune and inflammatory systems are controlled by multiple cytokines, including interleukins (ILs) and interferons. These cytokines exert their biological functions through Janus tyrosine kinases (JAKs) and STAT transcription factors. The CIS (cytokine-inducible SH2 protein) and SOCS (suppressors of cytokine signaling) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in inflammatory diseases. Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways.

Original languageEnglish
Pages (from-to)72-86
Number of pages15
JournalReviews of physiology, biochemistry and pharmacology
Publication statusPublished - 2003


ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Physiology (medical)

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