Negative regulation of cytokine signaling in immunity

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13 Citations (Scopus)

Abstract

Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of transcription (JAK-STAT) pathway to promote gene transcriptional regulation, but their signals must be attenuated by multiple mechanisms. These include the suppressors of cytokine signaling (SOCS) family of proteins, which represent a main negative regulation mechanism for the JAK-STAT pathway. Cytokine-inducible Src homology 2 (SH2)-containing protein (CIS), SOCS1, and SOCS3 proteins regulate cytokine signals that control the polarization of CD4+ T cells and the maturation of CD8+ T cells. SOCS proteins also regulate innate immune cells and are involved in tumorigenesis. This review summarizes recent progress on CIS, SOCS1, and SOCS3 in T cells and tumor immunity.

Original languageEnglish
Article numbera028571
JournalCold Spring Harbor perspectives in biology
Volume10
Issue number7
DOIs
Publication statusPublished - 2018 Jul 1

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Immunity
Suppressor of Cytokine Signaling Proteins
T-cells
Cytokines
Janus Kinases
Transducers
T-Lymphocytes
Transcription
Proteins
Carcinogenesis
Gene expression
Modulators
Tumors
Polarization
Genes
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Negative regulation of cytokine signaling in immunity",
abstract = "Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of transcription (JAK-STAT) pathway to promote gene transcriptional regulation, but their signals must be attenuated by multiple mechanisms. These include the suppressors of cytokine signaling (SOCS) family of proteins, which represent a main negative regulation mechanism for the JAK-STAT pathway. Cytokine-inducible Src homology 2 (SH2)-containing protein (CIS), SOCS1, and SOCS3 proteins regulate cytokine signals that control the polarization of CD4+ T cells and the maturation of CD8+ T cells. SOCS proteins also regulate innate immune cells and are involved in tumorigenesis. This review summarizes recent progress on CIS, SOCS1, and SOCS3 in T cells and tumor immunity.",
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AU - Yoshimura, Akihiko

AU - Ito, Minako

AU - Chikuma, Shunsuke

AU - Akanuma, Takashi

AU - Nakatsukasa, Hiroko

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