Neocomplanines A and B, a complanine family isolated from the marine fireworm

Kazuhiko Nakamura, Yu Tachikawa, Osamu Ohno, Makoto Kitamura, Masami Suganuma, Daisuke Uemura

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two new members of the complanine family, neocomplanines A (2) and B (3), were isolated as minor components of the methanolic extract of the "marine fireworm" Eurythoe complanata. The structures of the neocomplanines were revealed spectroscopically to be a trimetliylammonium unit with a saturated carbon chain. The planar structures of neocomplanines A and B were confirmed successfully through total syntheses that used epichlorohydrin as a starting material. The neocomplanines show inflammatory activity and also enhanced PKC activity in combination with TPA in the presence of Ca2+ in vitro; both are similar to the effects of complanine (1). The molecular mechanism of the effects of complanine-related compounds is discussed.

Original languageEnglish
Pages (from-to)303-305
Number of pages3
JournalJournal of Natural Products
Volume73
Issue number3
DOIs
Publication statusPublished - 2010 Mar 26

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Nakamura, K., Tachikawa, Y., Ohno, O., Kitamura, M., Suganuma, M., & Uemura, D. (2010). Neocomplanines A and B, a complanine family isolated from the marine fireworm. Journal of Natural Products, 73(3), 303-305. https://doi.org/10.1021/np900694j