Neocomplanines A and B, a complanine family isolated from the marine fireworm

Kazuhiko Nakamura, Yu Tachikawa, Osamu Ohno, Makoto Kitamura, Masami Suganuma, Daisuke Uemura

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Two new members of the complanine family, neocomplanines A (2) and B (3), were isolated as minor components of the methanolic extract of the "marine fireworm" Eurythoe complanata. The structures of the neocomplanines were revealed spectroscopically to be a trimetliylammonium unit with a saturated carbon chain. The planar structures of neocomplanines A and B were confirmed successfully through total syntheses that used epichlorohydrin as a starting material. The neocomplanines show inflammatory activity and also enhanced PKC activity in combination with TPA in the presence of Ca2+ in vitro; both are similar to the effects of complanine (1). The molecular mechanism of the effects of complanine-related compounds is discussed.

Original languageEnglish
Pages (from-to)303-305
Number of pages3
JournalJournal of Natural Products
Volume73
Issue number3
DOIs
Publication statusPublished - 2010 Mar 26

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Epichlorohydrin
Carbon
complanine
neocomplanine B
neocomplanine A
In Vitro Techniques

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Nakamura, K., Tachikawa, Y., Ohno, O., Kitamura, M., Suganuma, M., & Uemura, D. (2010). Neocomplanines A and B, a complanine family isolated from the marine fireworm. Journal of Natural Products, 73(3), 303-305. https://doi.org/10.1021/np900694j

Neocomplanines A and B, a complanine family isolated from the marine fireworm. / Nakamura, Kazuhiko; Tachikawa, Yu; Ohno, Osamu; Kitamura, Makoto; Suganuma, Masami; Uemura, Daisuke.

In: Journal of Natural Products, Vol. 73, No. 3, 26.03.2010, p. 303-305.

Research output: Contribution to journalArticle

Nakamura, K, Tachikawa, Y, Ohno, O, Kitamura, M, Suganuma, M & Uemura, D 2010, 'Neocomplanines A and B, a complanine family isolated from the marine fireworm', Journal of Natural Products, vol. 73, no. 3, pp. 303-305. https://doi.org/10.1021/np900694j
Nakamura K, Tachikawa Y, Ohno O, Kitamura M, Suganuma M, Uemura D. Neocomplanines A and B, a complanine family isolated from the marine fireworm. Journal of Natural Products. 2010 Mar 26;73(3):303-305. https://doi.org/10.1021/np900694j
Nakamura, Kazuhiko ; Tachikawa, Yu ; Ohno, Osamu ; Kitamura, Makoto ; Suganuma, Masami ; Uemura, Daisuke. / Neocomplanines A and B, a complanine family isolated from the marine fireworm. In: Journal of Natural Products. 2010 ; Vol. 73, No. 3. pp. 303-305.
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