Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Thomas Parlowsky, Julia Welzel, Masayuki Amagai, Detlef Zillikens, Thorsten Wygold

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.

Original languageEnglish
Pages (from-to)623-625
Number of pages3
JournalJournal of the American Academy of Dermatology
Volume48
Issue number4
DOIs
Publication statusPublished - 2003 Apr 1

Fingerprint

Desmoglein 3
Pemphigus
Blister
Autoantibodies
Immunoglobulin G
Skin
Indirect Fluorescent Antibody Technique
Fluorescence Microscopy
Foot
Enzyme-Linked Immunosorbent Assay
Head

ASJC Scopus subject areas

  • Dermatology

Cite this

Neonatal pemphigus vulgaris : IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns. / Parlowsky, Thomas; Welzel, Julia; Amagai, Masayuki; Zillikens, Detlef; Wygold, Thorsten.

In: Journal of the American Academy of Dermatology, Vol. 48, No. 4, 01.04.2003, p. 623-625.

Research output: Contribution to journalArticle

Parlowsky, Thomas ; Welzel, Julia ; Amagai, Masayuki ; Zillikens, Detlef ; Wygold, Thorsten. / Neonatal pemphigus vulgaris : IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns. In: Journal of the American Academy of Dermatology. 2003 ; Vol. 48, No. 4. pp. 623-625.
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