Neonatal pemphigus vulgaris: IgG4 autoantibodies to desmoglein 3 induce skin blisters in newborns

Thomas Parlowsky, Julia Welzel, Masayuki Amagai, Detlef Zillikens, Thorsten Wygold

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We report a case of neonatal pemphigus vulgaris presenting with skin lesions on the head, genital area, and right foot. Pemphigus vulgaris was diagnosed by the presence of circulating autoantibodies predominantly of the IgG4 subtype by indirect immunofluorescence microscopy and by enzyme-linked immunosorbent assay using recombinant desmoglein 3. This case demonstrates the pathogenic relevance of IgG4 autoantibodies to desmoglein 3 in the skin of neonates.

Original languageEnglish
Pages (from-to)623-625
Number of pages3
JournalJournal of the American Academy of Dermatology
Issue number4
Publication statusPublished - 2003 Apr 1


ASJC Scopus subject areas

  • Dermatology

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