Neoplastic endocrine differentiation of pancreatic ductal adenocarcinoma in a metastatic lymph node: Report of a case

Tomotaka Akatsu, Kaori Kameyama, Yuki Nogami, Shigeyuki Kawachi, Masaki Kitajima, Yuko Kitagawa

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The occurrence of non-neoplastic, scattered endocrine cells in pancreatic ductal adenocarcinoma (DAC) is thought to be a general phenomenon. Conversely, neoplastic endocrine differentiation (NED) of pancreatic DAC is extremely unusual. We report a case of NED in a metastatic lymph node from pancreatic DAC. This case is distinct because the main tumor of the pancreas was composed purely of DAC without endocrine differentiation, and the NED was found in only one of four metastatic peripancreatic lymph nodes. To our knowledge, no other such case has ever been reported. The patient was a 61-year-old woman who underwent pylorus-preserving pancreaticoduodenectomy for pancreatic head cancer. Some authors reported that pancreatic DAC with endocrine differentiation was associated with a better prognosis than DAC without endocrine differentiation. However, more cases must be studied to investigate the impact of NED of metastatic lymph nodes in pancreatic DAC.

Original languageEnglish
Pages (from-to)1009-1012
Number of pages4
JournalSurgery today
Volume37
Issue number11
DOIs
Publication statusPublished - 2007 Nov 1

Keywords

  • Metastatic lymph node
  • Neoplastic endocrine differentiation
  • Pancreatic ductal adenocarcinoma

ASJC Scopus subject areas

  • Surgery

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