TY - JOUR
T1 - Neoplastic endocrine differentiation of pancreatic ductal adenocarcinoma in a metastatic lymph node
T2 - Report of a case
AU - Akatsu, Tomotaka
AU - Kameyama, Kaori
AU - Nogami, Yuki
AU - Kawachi, Shigeyuki
AU - Kitajima, Masaki
AU - Kitagawa, Yuko
PY - 2007/11/1
Y1 - 2007/11/1
N2 - The occurrence of non-neoplastic, scattered endocrine cells in pancreatic ductal adenocarcinoma (DAC) is thought to be a general phenomenon. Conversely, neoplastic endocrine differentiation (NED) of pancreatic DAC is extremely unusual. We report a case of NED in a metastatic lymph node from pancreatic DAC. This case is distinct because the main tumor of the pancreas was composed purely of DAC without endocrine differentiation, and the NED was found in only one of four metastatic peripancreatic lymph nodes. To our knowledge, no other such case has ever been reported. The patient was a 61-year-old woman who underwent pylorus-preserving pancreaticoduodenectomy for pancreatic head cancer. Some authors reported that pancreatic DAC with endocrine differentiation was associated with a better prognosis than DAC without endocrine differentiation. However, more cases must be studied to investigate the impact of NED of metastatic lymph nodes in pancreatic DAC.
AB - The occurrence of non-neoplastic, scattered endocrine cells in pancreatic ductal adenocarcinoma (DAC) is thought to be a general phenomenon. Conversely, neoplastic endocrine differentiation (NED) of pancreatic DAC is extremely unusual. We report a case of NED in a metastatic lymph node from pancreatic DAC. This case is distinct because the main tumor of the pancreas was composed purely of DAC without endocrine differentiation, and the NED was found in only one of four metastatic peripancreatic lymph nodes. To our knowledge, no other such case has ever been reported. The patient was a 61-year-old woman who underwent pylorus-preserving pancreaticoduodenectomy for pancreatic head cancer. Some authors reported that pancreatic DAC with endocrine differentiation was associated with a better prognosis than DAC without endocrine differentiation. However, more cases must be studied to investigate the impact of NED of metastatic lymph nodes in pancreatic DAC.
KW - Metastatic lymph node
KW - Neoplastic endocrine differentiation
KW - Pancreatic ductal adenocarcinoma
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U2 - 10.1007/s00595-007-3521-9
DO - 10.1007/s00595-007-3521-9
M3 - Article
C2 - 17952537
AN - SCOPUS:35448955730
SN - 0941-1291
VL - 37
SP - 1009
EP - 1012
JO - Surgery Today
JF - Surgery Today
IS - 11
ER -
