Nephroprotective effect and its mechanism of betamipron (2) —Relationships of renal excretion—

Hideo Naganuma; Yasukuni Hirouchi; Yukinori Kawahara; Ken Ichi Inui; Yusuke Tanigawara; Masato Yasuhara; Ryohei Hori; Shogo Kuwahara

doi:10.11250/chemotherapy1953.39.Supplement3_178

Nephroprotective effect and its mechanism of betamipron (2) —Relationships of renal excretion—

Hideo Naganuma, Yasukuni Hirouchi, Yukinori Kawahara, Ken Ichi Inui, Yusuke Tanigawara, Masato Yasuhara, Ryohei Hori, Shogo Kuwahara

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Renal excretion mechanisms of panipenem (PAPM) and betamipron (BP) in rabbit were investigated by clearance techniques in vivo. The renal clearance (CLr) of PAPM under steady state exhibited 1 to 1.5-fold of glomerular filtration rate (GFR) and significantly decreased by the concomitant dose of BP. Similar decrement of CLr was found after treatment of some organic anions, probenecid or iodopyracet, but not p-aminohippuric acid. Organic cations such as N₁-methylnicotinamide and tetraethylammonium did not affect on the renal excretion of PAPM. BP and probenecid remarkably inhibited their CLr each other. Stop-flow analysis confirmed that both PAPM and BP were predominately secreted from renal proximal tubule. Concomitant intravenous dose of BP decreased the urinary excretion rate constant of cephaloridine (CER) and cephalexin (CEX) without any change of other pharmacokinetic parameters.

Original language	English
Pages (from-to)	178-189
Number of pages	12
Journal	Chemotherapy
Volume	39
DOIs	https://doi.org/10.11250/chemotherapy1953.39.Supplement3_178
Publication status	Published - 1991 Jan 1
Externally published	Yes

ASJC Scopus subject areas

Pharmacology (medical)
Infectious Diseases
Pharmacology
Drug Discovery
Oncology

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10.11250/chemotherapy1953.39.Supplement3_178

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abstract = "Renal excretion mechanisms of panipenem (PAPM) and betamipron (BP) in rabbit were investigated by clearance techniques in vivo. The renal clearance (CLr) of PAPM under steady state exhibited 1 to 1.5-fold of glomerular filtration rate (GFR) and significantly decreased by the concomitant dose of BP. Similar decrement of CLr was found after treatment of some organic anions, probenecid or iodopyracet, but not p-aminohippuric acid. Organic cations such as N1-methylnicotinamide and tetraethylammonium did not affect on the renal excretion of PAPM. BP and probenecid remarkably inhibited their CLr each other. Stop-flow analysis confirmed that both PAPM and BP were predominately secreted from renal proximal tubule. Concomitant intravenous dose of BP decreased the urinary excretion rate constant of cephaloridine (CER) and cephalexin (CEX) without any change of other pharmacokinetic parameters.",

author = "Hideo Naganuma and Yasukuni Hirouchi and Yukinori Kawahara and Inui, {Ken Ichi} and Yusuke Tanigawara and Masato Yasuhara and Ryohei Hori and Shogo Kuwahara",

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AU - Hirouchi, Yasukuni

AU - Kawahara, Yukinori

AU - Inui, Ken Ichi

AU - Tanigawara, Yusuke

AU - Yasuhara, Masato

AU - Hori, Ryohei

AU - Kuwahara, Shogo

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Renal excretion mechanisms of panipenem (PAPM) and betamipron (BP) in rabbit were investigated by clearance techniques in vivo. The renal clearance (CLr) of PAPM under steady state exhibited 1 to 1.5-fold of glomerular filtration rate (GFR) and significantly decreased by the concomitant dose of BP. Similar decrement of CLr was found after treatment of some organic anions, probenecid or iodopyracet, but not p-aminohippuric acid. Organic cations such as N1-methylnicotinamide and tetraethylammonium did not affect on the renal excretion of PAPM. BP and probenecid remarkably inhibited their CLr each other. Stop-flow analysis confirmed that both PAPM and BP were predominately secreted from renal proximal tubule. Concomitant intravenous dose of BP decreased the urinary excretion rate constant of cephaloridine (CER) and cephalexin (CEX) without any change of other pharmacokinetic parameters.

AB - Renal excretion mechanisms of panipenem (PAPM) and betamipron (BP) in rabbit were investigated by clearance techniques in vivo. The renal clearance (CLr) of PAPM under steady state exhibited 1 to 1.5-fold of glomerular filtration rate (GFR) and significantly decreased by the concomitant dose of BP. Similar decrement of CLr was found after treatment of some organic anions, probenecid or iodopyracet, but not p-aminohippuric acid. Organic cations such as N1-methylnicotinamide and tetraethylammonium did not affect on the renal excretion of PAPM. BP and probenecid remarkably inhibited their CLr each other. Stop-flow analysis confirmed that both PAPM and BP were predominately secreted from renal proximal tubule. Concomitant intravenous dose of BP decreased the urinary excretion rate constant of cephaloridine (CER) and cephalexin (CEX) without any change of other pharmacokinetic parameters.

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Nephroprotective effect and its mechanism of betamipron (2) —Relationships of renal excretion—

Abstract

ASJC Scopus subject areas

UN SDGs

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