Abstract
There have so far been few reports of the pharmacokinetics of oxaliplatin in patients with renal impairment. This report describes the nephrotoxicity induced by repeated cycles of oxaliplatin in a Japanese colorectal cancer patient with moderate renal impairment (creatinine clearance (Ccr): 20-30 mL/min). The patient was a 77-year-old male who had chronic renal impairment and received the modified FOLFOX6 repeated every 2 weeks. In cycle 8, the blood concentration of oxaliplatin (66 mg/m2) was measured as the platinum level to confirm the patient's safety. The serum ultrafiltrate concentrations of platinum were 800, 1,000, 300, <200, and <200 ng/mL at 1, 2, 3 hr, 1 week, and 2 weeks after the start of infusion, respectively, which were closely comparable with the population pharmacokinetic data in Japanese patients with normal renal function. On the other hand, the serum creatinine value was gradually increased after cycle 6, resulting in a decrease of Ccr. The mean Ccr during day 1-59 and day 240-299 were significantly different at 26.5±2.8 (mean±SD) and 9.6±1.9 mL/min, respectively. Consequently, the chemotherapy showed a complete response after 10 cycles, but the patient got dialysis on day 311. In conclusion, the repeated cycles of oxaliplatin cumulatively damaged the renal function in a Japanese patient with a moderate renal impairment.
| Original language | English |
|---|---|
| Pages (from-to) | 1153-1157 |
| Number of pages | 5 |
| Journal | Japanese Journal of Cancer and Chemotherapy |
| Volume | 37 |
| Issue number | 6 |
| Publication status | Published - 2010 Jan 1 |
| Externally published | Yes |
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Keywords
- Oxaliplatin
- Pharmacokinetics
- Toxicity
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Nephrotoxicity induced by repeated cycles of oxaliplatin in a Japanese colorectal cancer patient with moderate renal impairment. / Kawazoe, Hitoshi; Sugishita, Hiroki; Watanabe, Shinichi; Tanaka, Akihiro; Morioka, Jyunko; Suemaru, Katsuya; Watanabe, Yuji; Kawachi, Kanji; Araki, Hiroaki.
In: Japanese Journal of Cancer and Chemotherapy, Vol. 37, No. 6, 01.01.2010, p. 1153-1157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Nephrotoxicity induced by repeated cycles of oxaliplatin in a Japanese colorectal cancer patient with moderate renal impairment
AU - Kawazoe, Hitoshi
AU - Sugishita, Hiroki
AU - Watanabe, Shinichi
AU - Tanaka, Akihiro
AU - Morioka, Jyunko
AU - Suemaru, Katsuya
AU - Watanabe, Yuji
AU - Kawachi, Kanji
AU - Araki, Hiroaki
PY - 2010/1/1
Y1 - 2010/1/1
N2 - There have so far been few reports of the pharmacokinetics of oxaliplatin in patients with renal impairment. This report describes the nephrotoxicity induced by repeated cycles of oxaliplatin in a Japanese colorectal cancer patient with moderate renal impairment (creatinine clearance (Ccr): 20-30 mL/min). The patient was a 77-year-old male who had chronic renal impairment and received the modified FOLFOX6 repeated every 2 weeks. In cycle 8, the blood concentration of oxaliplatin (66 mg/m2) was measured as the platinum level to confirm the patient's safety. The serum ultrafiltrate concentrations of platinum were 800, 1,000, 300, <200, and <200 ng/mL at 1, 2, 3 hr, 1 week, and 2 weeks after the start of infusion, respectively, which were closely comparable with the population pharmacokinetic data in Japanese patients with normal renal function. On the other hand, the serum creatinine value was gradually increased after cycle 6, resulting in a decrease of Ccr. The mean Ccr during day 1-59 and day 240-299 were significantly different at 26.5±2.8 (mean±SD) and 9.6±1.9 mL/min, respectively. Consequently, the chemotherapy showed a complete response after 10 cycles, but the patient got dialysis on day 311. In conclusion, the repeated cycles of oxaliplatin cumulatively damaged the renal function in a Japanese patient with a moderate renal impairment.
AB - There have so far been few reports of the pharmacokinetics of oxaliplatin in patients with renal impairment. This report describes the nephrotoxicity induced by repeated cycles of oxaliplatin in a Japanese colorectal cancer patient with moderate renal impairment (creatinine clearance (Ccr): 20-30 mL/min). The patient was a 77-year-old male who had chronic renal impairment and received the modified FOLFOX6 repeated every 2 weeks. In cycle 8, the blood concentration of oxaliplatin (66 mg/m2) was measured as the platinum level to confirm the patient's safety. The serum ultrafiltrate concentrations of platinum were 800, 1,000, 300, <200, and <200 ng/mL at 1, 2, 3 hr, 1 week, and 2 weeks after the start of infusion, respectively, which were closely comparable with the population pharmacokinetic data in Japanese patients with normal renal function. On the other hand, the serum creatinine value was gradually increased after cycle 6, resulting in a decrease of Ccr. The mean Ccr during day 1-59 and day 240-299 were significantly different at 26.5±2.8 (mean±SD) and 9.6±1.9 mL/min, respectively. Consequently, the chemotherapy showed a complete response after 10 cycles, but the patient got dialysis on day 311. In conclusion, the repeated cycles of oxaliplatin cumulatively damaged the renal function in a Japanese patient with a moderate renal impairment.
KW - Oxaliplatin
KW - Pharmacokinetics
KW - Toxicity
UR - http://www.scopus.com/inward/record.url?scp=79960828844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960828844&partnerID=8YFLogxK
M3 - Article
C2 - 20567127
AN - SCOPUS:79960828844
VL - 37
SP - 1153
EP - 1157
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 6
ER -