Nephrotoxicity induced by repeated cycles of oxaliplatin in a Japanese colorectal cancer patient with moderate renal impairment

Hitoshi Kawazoe, Hiroki Sugishita, Shinichi Watanabe, Akihiro Tanaka, Jyunko Morioka, Katsuya Suemaru, Yuji Watanabe, Kanji Kawachi, Hiroaki Araki

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5 Citations (Scopus)

Abstract

There have so far been few reports of the pharmacokinetics of oxaliplatin in patients with renal impairment. This report describes the nephrotoxicity induced by repeated cycles of oxaliplatin in a Japanese colorectal cancer patient with moderate renal impairment (creatinine clearance (Ccr): 20-30 mL/min). The patient was a 77-year-old male who had chronic renal impairment and received the modified FOLFOX6 repeated every 2 weeks. In cycle 8, the blood concentration of oxaliplatin (66 mg/m2) was measured as the platinum level to confirm the patient's safety. The serum ultrafiltrate concentrations of platinum were 800, 1,000, 300, <200, and <200 ng/mL at 1, 2, 3 hr, 1 week, and 2 weeks after the start of infusion, respectively, which were closely comparable with the population pharmacokinetic data in Japanese patients with normal renal function. On the other hand, the serum creatinine value was gradually increased after cycle 6, resulting in a decrease of Ccr. The mean Ccr during day 1-59 and day 240-299 were significantly different at 26.5±2.8 (mean±SD) and 9.6±1.9 mL/min, respectively. Consequently, the chemotherapy showed a complete response after 10 cycles, but the patient got dialysis on day 311. In conclusion, the repeated cycles of oxaliplatin cumulatively damaged the renal function in a Japanese patient with a moderate renal impairment.

Original languageEnglish
Pages (from-to)1153-1157
Number of pages5
JournalJapanese Journal of Cancer and Chemotherapy
Volume37
Issue number6
Publication statusPublished - 2010 Jun
Externally publishedYes

Keywords

  • Oxaliplatin
  • Pharmacokinetics
  • Toxicity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Kawazoe, H., Sugishita, H., Watanabe, S., Tanaka, A., Morioka, J., Suemaru, K., Watanabe, Y., Kawachi, K., & Araki, H. (2010). Nephrotoxicity induced by repeated cycles of oxaliplatin in a Japanese colorectal cancer patient with moderate renal impairment. Japanese Journal of Cancer and Chemotherapy, 37(6), 1153-1157.